H0541

Anti-HOXB7 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-HHO.C1, Anti-HOX2, Anti-HOX2C, Anti-Hox-2.3
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~24 kDa
• species reactivity: human
• concentration: ~1.0 mg/mL
• technique(s): immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human HOXB7; indirect immunofluorescence: 1-2 μg/mL using using paraformaldehyde fixed HEK-293T cells over expressing human HOXB7; western blot: 1-2 μg/mL using extracts of HEK-293T cells over expressing human HOXB7
• UniProt accession no.: P09629
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... HOXB7(3217) ; mouse ... Hoxb7(15415)

Description

General description

Homeobox B7 (HOXB7) gene is mapped to human chromosome 17q21.32. In vertebrates, 39 HOX genes are organized into four clusters (HOXA-HOXD), located on different chromosomes (7p15, 17q21.2, 12q13, and 2q31). HOX proteins have a highly conserved 60-amino-acid region (the homeobox).

Specificity

Anti-HOXB7 (C-terminal) recognizes human HOXB7 (also known as HOX2; HOX2C; HHO.

Application

Anti-HOXB7 (C-terminal) antibody produced in rabbit may be used in immunoblotting.

Biochem/physiol Actions

The homeobox with DNA-binding activity, contributes to their activity as transcription factors. Hox genes are evolutionarily conserved transcription factors, which act to control important development pathways involved in the morphogenesis of the embryo. HOXB7 is expressed in various human hematopoietic cell lines and tissues as well as in proliferating melanocytes. In addition to roles in normal development, altered homeobox gene function or expression is implicated in carcinomas associated with breast, prostate, kidney, colon, skin and brain.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable