H0532
Heparin-Ceramic HyperD M Hydrogel Composite
saline suspension with ethanol, 80 μm mean particle size
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form
saline suspension with ethanol
matrix
Ceramic HyperD M Hydrogel Composite
mean particle size
80 μm
capacity
≥20 mg/mL binding capacity (antithrombin III)
storage temp.
2-8°C
Application
Heparin-Ceramic HyperD M Hydrogel is used in affinity chromatography and protein chromatography. Studies have shown promise for employing heparin-based hydrogels as matrices for in vitro differentiation of hepatocytes or stem cells and as vehicles for transplantation of these cells.
Features and Benefits
Characteristics are tolerance of very high flow rates without bed compression, and high exchange capacity. Stable to most common solvents, and pH from 2-12.
Other Notes
HyperD media are highly porous, rigid ceramic beads filled with a derivatized hydrogel.
Physical form
Suspension in 1 M NaCl with 20% ethanol
signalword
Warning
hcodes
Hazard Classifications
Flam. Liq. 3
Storage Class
3 - Flammable liquids
wgk_germany
WGK 1
flash_point_f
73.4 °F
flash_point_c
23 °C
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Mihye Kim et al.
Biomaterials, 31(13), 3596-3603 (2010-02-16)
Primary hepatocytes are commonly used as liver surrogates in toxicology and tissue engineering fields, therefore, maintenance of functional hepatocytes in vitro is an important topic of investigation. This paper sought to characterize heparin-based hydrogel as a three-dimensional scaffold for hepatocyte
Karolina Chwalek et al.
Biomaterials, 32(36), 9649-9657 (2011-09-23)
Cell-responsive degradation of biofunctional scaffold materials is required in many tissue engineering strategies and commonly achieved by the incorporation of protease-sensitive oligopeptide units. In extension of this approach, we combined protease-sensitive and -insensitive cleavage sites for the far-reaching control over
Uwe Freudenberg et al.
Biomaterials, 30(28), 5049-5060 (2009-06-30)
Biofunctional matrices for in vivo tissue engineering strategies must be modifiable in both biomolecular composition and mechanical characteristics. To address this challenge, we present a modular system of biohybrid hydrogels based on covalently cross-linked heparin and star-shaped poly(ethylene glycols) (star-PEG)
Arne Staby et al.
Journal of chromatography. A, 1069(1), 65-77 (2005-04-23)
A comparative study was performed on heparin resins and strong and weak cation exchangers to investigate the pH dependence, efficiency, binding strength, particle size distribution, static and dynamic capacity, and scanning electron microscopy pictures of chromatographic resins. The resins tested
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