H0416
Anti-HOXB5 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-HOMEOBOX 2A, Anti-HOMEOBOX B5, Anti-HOX-2A, Anti-HOX2.1, Anti-HU-1
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About This Item
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~40 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
western blot: 0.5-1 μg/mL using lysates of HEK-293T cells over-expressing human HOXB5
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HOXB5(3215)
mouse ... Hoxb5(15413)
General description
Hox genes are evolutionarily conserved transcription factors. Homeobox B5 (HOXB5) gene is mapped to human chromosome 17q21.32. HOX proteins have a highly conserved 60-amino-acid region (the homeobox).
Specificity
Anti-HOXB5 recognizes human HOXB5 (also known as HOX-2A, HU-1 and Hox2.
Immunogen
synthetic peptide corresponding to amino acids 103-121 of human HOXB5 conjugated to KLH. The corresponding sequence is identical in mouse.
Application
Anti-HOXB5 antibody produced in rabbit may be used in immunoblotting.
Biochem/physiol Actions
One of the major functions of Hox genes seems to be the formation of the body plan during embryonic development. Alteration in the homeobox gene function or expression is implicated in the development of cancers including the breast, prostate, kidney, colon, skin and brain. Studies have shown that HOXB5 is necessary for normal mouse lung branching morphogenesis, and its abnormal regulation causes specific alterations in airway branching. HOXB5 functional impairment is implicated in Hirschsprung′s disease. It also plays a key role in the development of the enteric nervous system. Elimination of the HOX5 gene suppresses β-catenin expression and downstream pathway, thereby inhibiting non-small cell lung cancer (NSCLC) tumor progression.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Bin Zhang et al.
Oncology research, 26(1), 37-44 (2017-03-25)
Homeobox B5 (HOXB5), a member of the HOX gene family, has been shown to play an important role in tumor progression. However, the expression and functional role of HOXB5 in human non-small cell lung cancer (NSCLC) have not been defined.
MaryAnn Vitoria Volpe et al.
Birth defects research. Part A, Clinical and molecular teratology, 82(8), 571-584 (2008-06-17)
Hox transcription factors modulate signaling pathways controlling organ morphogenesis and maintain cell fate and differentiation in adults. Retinoid signaling, key in regulating Hox expression, is altered in pulmonary hypoplasia. Information on pattern-specific expression of Hox proteins in normal lung development
M T Lewis
Breast cancer research : BCR, 2(3), 158-169 (2001-03-16)
Both normal development and neoplastic progression involve cellular transitions from one physiological state to another. Whereas much is being discovered about signal transduction networks involved in regulating these transitions, little progress has been made in identifying the higher order genetic
Yang Yang et al.
Molecular medicine reports, 16(3), 2773-2778 (2017-07-06)
Osteosarcoma is the most common primary malignant bone cancer in children and adolescents. Unfortunately, treatment failures are common due to metastasis and chemore-sistance, however, the underlying molecular mechanism remains unclear. Accumulating evidence indicated that the homeobox B7 (HOXB7) gene was
Nobumoto Tomioka et al.
Cancer genetics and cytogenetics, 201(1), 6-14 (2010-07-17)
Unlike the case with some other solid tumors, whole genome array screening has not revealed prognostic genetic aberrations in primary gastric cancer. Comparative genomic hybridization (CGH) using bacterial artificial chromosome (BAC) arrays for 56 primary gastric cancers resulted in identification
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