H0166
Anti-HOXB6 (N-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
Synonym(s):
Anti-HOX-2B, Anti-HOX2.2, Anti-HU-2, Anti-Homeo box 2B, Anti-Homeobox B6
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~30 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
western blot: 0.5-1 μg/mL using lysates of HEK-293T cells over expressing human HOXB6
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HOXB6(3216)
mouse ... Hoxb6(15414)
General description
Hox genes are evolutionarily conserved transcription factors. Homeobox B6 (HOXB6) gene is mapped to human chromosome 17q21.32. HOX proteins have a highly conserved 60-amino-acid region (the homeobox).
Specificity
Anti-HOXB6 (N-terminal) recognizes human HOXB6 (also known as HOX2B, HU-2 and Hox-2).
Immunogen
synthetic peptide corresponding to amino acids 48-60 of human HOXB6 conjugated to KLH. The corresponding sequence in mouse differs by one amino acid.
Application
Anti-HOXB6 (N-terminal) antibody produced in rabbit may be used in immunoblotting.
Biochem/physiol Actions
One of the major functions of Hox genes seems to be the formation of the body plan during embryonic development. Alteration in the homeobox gene function or expression is implicated in the development of cancers including the breast, prostate, kidney, colon, skin and brain. HOXB6 is frequently overexpressed in human acute myeloid leukemia (AML). Findings have indicated that HOXB6 overexpression expanded hematopoietic stem cells (HSCs) and myeloid precursors while impairing erythropoiesis and lymphopoiesis.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month.For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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A Giampaolo et al.
Leukemia, 16(7), 1293-1301 (2002-07-03)
Homeobox genes encode transcription factors known to be important morphogenic regulators during embryonic development. An increasing body of work implies a role for homeobox genes in both hematopoiesis and leukemogenesis. In the present study we have analyzed the role of
Yang Yang et al.
Molecular medicine reports, 16(3), 2773-2778 (2017-07-06)
Osteosarcoma is the most common primary malignant bone cancer in children and adolescents. Unfortunately, treatment failures are common due to metastasis and chemore-sistance, however, the underlying molecular mechanism remains unclear. Accumulating evidence indicated that the homeobox B7 (HOXB7) gene was
M T Lewis
Breast cancer research : BCR, 2(3), 158-169 (2001-03-16)
Both normal development and neoplastic progression involve cellular transitions from one physiological state to another. Whereas much is being discovered about signal transduction networks involved in regulating these transitions, little progress has been made in identifying the higher order genetic
Neal A Fischbach et al.
Blood, 105(4), 1456-1466 (2004-11-04)
The HOX family of homeobox genes plays an important role in normal and malignant hematopoiesis. Dysregulated HOX gene expression profoundly effects the proliferation and differentiation of hematopoietic stem cells (HSCs) and committed progenitors, and aberrant activation of HOX genes is
Nobumoto Tomioka et al.
Cancer genetics and cytogenetics, 201(1), 6-14 (2010-07-17)
Unlike the case with some other solid tumors, whole genome array screening has not revealed prognostic genetic aberrations in primary gastric cancer. Comparative genomic hybridization (CGH) using bacterial artificial chromosome (BAC) arrays for 56 primary gastric cancers resulted in identification
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