Immunogen Sequence: GI # 4502199, sequence 100-184
Recombinant amphiregulin preproprotein
Application
Anti-Amphiregulin antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Amphiregulin (AREG) is a protein encoded by the AREG gene in humans and is localized to chromosomal region 4q13-4q21, a common breakpoint for acute lymphoblastic leukemia. It is a bifunctional growth modulator that interacts with the EGF/TGF-α receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. The gene is related to epidermal growth factor (EGF) and transforming growth factor α (TGF-α). AREG is a widely expressed transmembrane tyrosine kinase and is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. It plays a critical role in the development and maturation of mammary glands, bone tissue and oocytes. Increased expression of the gene is associated with different pathological conditions (mostly of inflammatory and/or neoplastic nature). AREG is useful in primary colorectal tumor as an indicator of prognosis and as a predictor of recurrence.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular and cellular biology, 10(5), 1969-1981 (1990-05-01)
We have isolated the gene for a novel growth regulator, amphiregulin (AR), that is evolutionarily related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). AR is a bifunctional growth modulator: it interacts with the EGF/TGF-alpha receptor to
Amphiregulin is an epidermal growth factor (EGF) which is a ligand of epidermal growth factor receptor (EGFR). Amphiregulin is the most enhanced EGFR ligand in colon cancer. Here we report on the expression of Amphiregulin using immunohistochemical staining in primary
Seminars in cell & developmental biology, 28, 31-41 (2014-01-28)
Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by
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