GW22843
Anti-TXLNA antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Taxilin
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-22843
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TXLNA(200081)
Biochem/physiol Actions
α-taxilin, also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF), is a protein encoded by the TXLNA gene in humans. It belongs to taxilin family that mutually interacts with the syntaxin family members. It acts as a novel binding partner of the syntaxin family, which is implicated in intracellular vesicle traffic. α-taxilin regulate vesicular trafficking and plays an essential role for the release of hepatitis B virus-DNA (HBV-DNA) containing particles. It contains intracellular components that are associated with the microtubule cytoskeleton and functions as a linker protein between the α-taxilin-containing intracellular components and the microtubule cytoskeleton. α-taxilin may also be involved in cell proliferation of hepatocellular carcinomas (HCC) and its expression can be a marker of malignant potential of HCC.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Jasmin Hoffmann et al.
Journal of hepatology, 59(5), 934-941 (2013-07-03)
α-taxilin was identified as binding partner of syntaxins and is supposed to regulate vesicular trafficking. However, the physiological functions of α-taxilin and its potential relevance for the life cycle of hepatitis B virus (HBV) are still poorly understood. Transfected hepatoma
Satoru Nogami et al.
Biochemical and biophysical research communications, 311(4), 797-802 (2003-11-19)
Taxilin is novel binding partner of the syntaxin family, which is implicated in intracellular vesicle traffic. However, precise binding properties of taxilin to the syntaxin family remain to be clarified. Then, we here further investigated the interaction of taxilin with
Natsuko Ohtomo et al.
International journal of oncology, 37(6), 1417-1423 (2010-11-03)
The membrane traffic system has been recognized to be involved in carcinogenesis and tumor progression in several types of tumors. α-taxilin is a newly identified membrane traffic-related molecule, and its up-regulation has been reported in embryonic and malignant tissues of
Satoru Nogami et al.
Biochemical and biophysical research communications, 319(3), 936-943 (2004-06-09)
The syntaxin family is implicated in intracellular vesicle traffic. We have recently identified taxilin, a novel syntaxin-binding protein, which has a long coiled-coil region in its C-terminal half. A database search has revealed the presence of two other molecules having
Yukimi Horii et al.
Cell structure and function, 37(2), 111-126 (2012-07-13)
Intracellular vesicle traffic plays an essential role in the establishment and maintenance of organelle identity and biosynthetic transport. We have identified α-taxilin as a binding partner of the syntaxin family, which is involved in intracellular vesicle traffic. Recently, we have
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