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GW22835

Sigma-Aldrich

Anti-SLC7A9 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-22835

technique(s)

indirect ELISA: suitable

NCBI accession no.

NP_055085.1

UniProt accession no.

P82251

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SLC7A9(11136)

Immunogen

Immunogen Sequence: GI # 7657591, sequence 3-19
Synthetic peptide sequence of solute carrier family 7 (cationic amino acid transporter, y+ system), member 9.

Application

Anti-SLC7A9 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Solute carrier family 7 member 9 is a protein encoded by the SLC7A9 gene in humans and is mapped on chromosome 19q. Mutation of this gene encodes for amino acid transport systems that are responsible for different types of cystinuria (is an autosomal recessive disorder caused by defective transport of cystine and the dibasic amino acids ornithine, lysine and arginine across cell membranes). The polymorphic background of the gene may affect the expression of the disorder in SLC7A9 mutation carriers.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
039K2190
029K1936

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O Y Al-Dirbashi et al.
Journal of inherited metabolic disease, 30(4), 611-611 (2007-08-19)
Cystinuria is an autosomal recessive disorder caused by defective transport of cystine and the dibasic amino acids ornithine, lysine and arginine across cell membranes. Poor solubility of cystine in urine leads to kidney stones and associated symptoms and complications. Mutations
Anthoula Chatzikyriakidou et al.
Urological research, 34(5), 299-303 (2006-07-14)
Cystinuria is a complex genetic disorder. In the present study, we report on the strict linkage disequilibrium of SLC7A9 mutations with the wild type SLC7A9 haplotype of 15 single nucleotide polymorphisms (SNPs) and their effect on cystinuria manifestation and classification.
Danny Lotan et al.
The Israel Medical Association journal : IMAJ, 9(7), 513-516 (2007-08-23)
Cystinuria is an autosomal recessive disease that is manifested by kidney stones and is caused by mutations in two genes: SLC3AI on chromosome 2p and SLC7A9 on chromosome 19q. Urinary cystine levels in obligate carriers are often, but not always

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