GW22828

Anti-PDIA6 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: chicken
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human, rat
• manufacturer/tradename: Genway 15-288-22828
• technique(s): western blot: suitable
• NCBI accession no.: NP_005733.1
• UniProt accession no.: Q15084
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... PDIA6(10130)

Description

General description

PDIA6 (also known as ERP5) is an endoplasmic reticulum (ER)-resident protein found mainly on platelet intracellular membranes. It is translocated to the surface of epithelial tumor cells. It possesses structural homology with protein disulfide isomerase (PDI). PDIA6 consists of two Cys-Gly-His-Cys (CGHC) sequences and the ER retention signal Lys-Asp-Glu-Leu.

Immunogen

Immunogen Sequence: GI # 5031973, sequence 301-440

Recombinant protein disulfide isomerase-associated 6

Application

Anti-PDIA6 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

PDIA6 (also known as ERP5) is involved in various activities such as chaperone, isomerase and peptide-binding activities. It is rapidly recruited to the cell surface in response to a range of platelet agonists. Blocking of cell-surface ERP5 by inhibitory antibodies leads to a decrease in platelet aggregation in response to agonists and a decrease in fibrinogen binding and P-selectin exposure. ERP5 is associated with integrin β(3) subunit during platelet stimulation.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)