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GW22824

Sigma-Aldrich

Anti-STIP1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
MFCD02686631
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human

manufacturer/tradename

Genway 15-288-22824

technique(s)

western blot: suitable

NCBI accession no.

NP_006810.1

UniProt accession no.

P31948

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... STIP1(10963)

Immunogen

Immunogen Sequence: GI # 5803181, sequence 301-543
Recombinant stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)

Application

Anti-STIP1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

STIP1 (also known as Hop) is one of the most extensively studied co-chaperones and is a member of the co-chaperone family, which directly binds to chaperones to regulate their activities. It has the ability to directly associate with both Hsp70 and Hsp90 in catalysis of protein folding and during maturation in cytosol. HOP changes its conformation in the presence of ATP. It acts as a biomarker in epithelial ovarian cancer (EOC). It also interacts with tubulin and colocalizes with microtubules in endothelial cells. HOP acts as a novel regulator of angiogenesis that functions through promoting vascular endothelial cell polarization and migration.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
118K1861
039K0548
029K2170

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Hanbyoul Cho et al.
Genes, chromosomes & cancer, 53(4), 277-288 (2014-02-04)
Stress-induced phosphoprotein1 (STIP1) is a candidate biomarker in epithelial ovarian cancer (EOC). In this study, we investigated in detail the expression of STIP1, as well as its functions, in EOC. STIP1 expression was assessed by immunohistochemistry (IHC) and the results
Soh Yamamoto et al.
The Journal of biological chemistry, 289(14), 9880-9886 (2014-02-19)
Co-chaperones help to maintain cellular homeostasis by modulating the activities of molecular chaperones involved in protein quality control. The HSP70/HSP90-organizing protein (HOP) is a co-chaperone that cooperates with HSP70 and HSP90 in catalysis of protein folding and maturation in the
O O Odunuga et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 26(10), 1058-1068 (2004-09-24)
Molecular chaperones facilitate the correct folding of other proteins under physiological and stress conditions. Recently it has become evident that various co-chaperone proteins regulate the cellular functions of these chaperones, particularly Hsp70 and Hsp90. Hop is one of the most
Jingyu Li et al.
PloS one, 7(4), e36389-e36389 (2012-05-05)
Hsp70/Hsp90-organizing protein (HOP) is a member of the co-chaperone family, which directly binds to chaperones to regulate their activities. The participation of HOP in cell motility and endothelial cell functions remains largely unknown. In this study, we demonstrate that HOP

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