GW22822
Anti-CABP1 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat
manufacturer/tradename
Genway 15-288-22822
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CALBRAIN(9478)
General description
The previously assigned protein identifier Q8N6H5 has been merged into Q9NZU7. Full details can be found on the UniProt database.
Immunogen
Immunogen Sequence: GI # 13929432, sequence 15-227
Recombinant calcium binding protein 1 isoform 1
Application
Anti-CABP1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Calcium binding protein 1 is a protein encoded by the CABP1 gene in humans and belongs to neuron-specific member of the calmodulin (CaM) superfamily. It is a 19.4kDa protein of the EF-hand superfamily that modulates the activity of Ca2+ channels in the brain and retina. CABP1 helps in regulating the Ca2+ -dependent activity of inositol 1,4,5-triphosphate receptors (InsP3Rs) and various voltage-gated Ca2+ channels. CaBP1 interacts with cytosolic N- and C-terminal domains and blunts Ca2+-dependent inactivation. It may regulate Ca2+-dependent activity of InsP3Rs by promoting structural contacts between the suppressor and core domains.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Jennifer N Wingard et al.
The Journal of biological chemistry, 280(45), 37461-37470 (2005-09-09)
CaBP1 (calcium-binding protein 1) is a 19.4-kDa protein of the EF-hand superfamily that modulates the activity of Ca(2+) channels in the brain and retina. Here we present data from NMR, microcalorimetry, and other biophysical studies that characterize Ca(2+) binding, Mg(2+)
CaBP1 regulates voltage-dependent inactivation and activation of Ca(V)1.2 (L-type) calcium channels.
Shimrit Oz et al.
The Journal of biological chemistry, 286(16), 13945-13953 (2011-03-09)
CaBP1 is a Ca(2+)-binding protein that regulates the gating of voltage-gated (Ca(V)) Ca(2+) channels. In the Ca(V)1.2 channel α(1)-subunit (α(1C)), CaBP1 interacts with cytosolic N- and C-terminal domains and blunts Ca(2+)-dependent inactivation. To clarify the role of the α(1C) N-terminal
Saebomi Park et al.
Protein science : a publication of the Protein Society, 20(8), 1356-1366 (2011-05-25)
Calcium-binding protein 1 (CaBP1), a neuron-specific member of the calmodulin (CaM) superfamily, regulates the Ca(2+) -dependent activity of inositol 1,4,5-triphosphate receptors (InsP3Rs) and various voltage-gated Ca(2+) channels. Here, we present the NMR structure of full-length CaBP1 with Ca(2+) bound at
Congmin Li et al.
The Journal of biological chemistry, 284(4), 2472-2481 (2008-11-15)
Calcium-binding protein 1 (CaBP1), a neuron-specific member of the calmodulin (CaM) superfamily, modulates Ca2+-dependent activity of inositol 1,4,5-trisphosphate receptors (InsP3Rs). Here we present NMR structures of CaBP1 in both Mg2+-bound and Ca2+-bound states and their structural interaction with InsP3Rs. CaBP1
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