GW22790
Anti-TLR9 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse
manufacturer/tradename
Genway 15-288-22790
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... TLR9(54106)
Immunogen
Immunogen Sequence: GI # 8394456, sequence 311-465
Recombinant toll-like receptor 9 isoform A
Application
Anti-TLR9 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Toll-like receptor 9 is a protein encoded by the TLR9 gene in humans. It is a cellular DNA-receptor and is widely expressed in breast as well as other cancers. It plays an important role in the pathogenesis of systemic lupus erythematosus (SLE) and has an impact on organ involvement in SLE. Expression of TLR-9 is a good indicator and helps in distinguishing cancer patients from benign and normal controls. TLR9 plays a crutial role in sensing a wide range of pathogens, including bacteria, fungi and viruses. Dysregulation of its signaling may contribute to a higher risk of developing cancers.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificates of Analysis (COA)
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Agnieszka Klonowska-Szymczyk et al.
Mediators of inflammation, 2014, 381418-381418 (2014-04-03)
Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown aetiology. The results of experimental studies point to the involvement of innate immunity receptors-toll-like receptors (TLR)-in the pathogenesis of the disease. The aim of the study was to assess the
Johanna Tuomela et al.
Breast cancer research and treatment, 142(3), 477-487 (2013-11-12)
TLR9 is a cellular DNA-receptor, which is widely expressed in breast and other cancers. Although synthetic TLR9-ligands induce cancer cell invasion in vitro, the role of TLR9 in cancer pathophysiology has remained unclear. We show here that living cancer cells
Qiong Dai et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(4), 3247-3253 (2014-02-08)
Toll-like receptor 9 (TLR9) plays a pivotal role in sensing a wide range of pathogens, including bacteria, fungi, and viruses. A dysregulation of TLR9 signaling may contribute to a higher risk of developing cancers. A hospital-based case-control study, including 356
Kanchan Karki et al.
DNA and cell biology, 33(9), 630-636 (2014-06-07)
The intracellular redox environment plays an important role in the maintenance of proper cellular homeostasis and functions. Disturbances in redox equilibrium of cells result in pro-inflammatory conditions, and these inflammatory conditions can induce carcinogenesis or increase the malignant potential of
Johanna Korvala et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 43(7), 530-537 (2014-02-04)
Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Although several biomarkers have been evaluated, histological grade remains the most valuable prognostic marker. Toll-like receptor 9 (TLR9) is an immune receptor recognizing microbial DNA. Its expression associates with prognosis
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