GW22776
Anti-AKT2 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-22776
technique(s)
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... AKT2(208)
Immunogen
Immunogen Sequence: GI # 4502023, sequence 108-124
Synthetic peptide sequence of V-akt murine thymoma viral oncogene homolog 2.
Application
Anti-AKT2 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
RAC-β serine/threonine-protein kinase is an enzyme encoded by the AKT2 gene in humans and is mapped to chromosome region 19q13.1-q13.2. It belongs to a distinct subfamily of protein-serine/threonine kinases containing Src homology 2-like domains. Alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas. The protein kinase is thought to be a key mediator of the insulin signal transduction process and plays a role in glucose metabolism. It also mediates the development or maintenance of proper adipose tissue and islet mass. It is an important protein in PI3K signaling pathway and is overexpressed in a variety of malignant tumors. AKT2 may be a useful molecular marker for predicting the prognosis of meningioma. It plays a novel role in neuroblastoma tumorigenesis and may be important for developing novel therapeutics for the treatment of clinically aggressive neuroblastoma.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Q Wang et al.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 40(9), 1056-1061 (2014-03-25)
AKT2 (protein kinase B), an important protein in PI3K signaling pathway, is overexpressed in a variety of malignant tumors. However, in patients with meningiomas, the potential correlation between AKT2 and clinical outcome remains unknown. The expression of AKT2 and Ki-67
Xiu-Qin Sun et al.
Chinese medical journal, 124(5), 725-728 (2011-04-27)
The Akt2 protein kinase is thought to be a key mediator of the insulin signal transduction process. Akt2 is suggested to play a role in glucose metabolism and the development or maintenance of proper adipose tissue and islet mass. In
J Q Cheng et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(19), 9267-9271 (1992-10-01)
We isolated cDNA clones containing the entire coding region of the putative oncogene AKT2. Sequence analysis and in vitro translation demonstrated that AKT2 encodes a 56-kDa protein with homology to serine/threonine kinases; moreover, this protein contains a Src homology 2-like
Jingbo Qiao et al.
PloS one, 8(2), e56382-e56382 (2013-03-08)
Activation of PI3K/AKT pathway correlates with poor prognosis in patients with neuroblastoma. Our previous studies have demonstrated that PI3K/AKT signaling is critical for the oncogenic transformations induced by gastrin-releasing peptide (GRP) and its receptor, GRP-R, in neuroblastoma. Moreover, PI3K/AKT-dependent oncogenic
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