GW22763
Anti-GAPDH antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Gapdh Antibody Sigma, Gapdh Antibody Sigma - Anti-GAPDH antibody produced in chicken
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About This Item
MDL number:
UNSPSC Code:
12352203
Recommended Products
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, mouse, human
manufacturer/tradename
Genway 15-288-22763
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GAPDH(2597)
Immunogen
Immunogen Sequence: GI # 7669492, sequence 51-290
Recombinant glyceraldehyde-3-phosphate dehydrogenase
Application
Anti-GAPDH antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
Glyceraldehyde 3-phosphate dehydrogenase (G3PDH) is an enzyme that catalyzes the sixth step of glycolysis and serves to break down glucose for energy and carbon molecules. It is an obligatory enzyme in glycolysis and performs a critical role in cellular regulation. GAPDH also plays a critical role in apoptosis and age-related neurodegenerative diseases, such as Alzheimer′s, Huntington′s and Parkinson′s diseases. Overexpression of this gene in resected tumor samples is an adverse prognostic factor in non-small cell lung cancers (NSCLC). It is used as a stable housekeeping marker for constant gene expression and its transcriptional levels may be highly up-regulated in some cancers.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Feng Zhao et al.
Oncology letters, 9(1), 159-164 (2014-12-02)
Hypermethylated in cancer 1 (HIC-1) is a tumor suppressor gene, which is epigenetically silenced in breast cancer. It is known that the loss of HIC-1, caused by promoter hypermethylation, is associated with tumor aggression and poor survival in breast carcinoma.
Dunrui Wang et al.
PloS one, 8(4), e61262-e61262 (2013-04-27)
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is often used as a stable housekeeping marker for constant gene expression. However, the transcriptional levels of GAPDH may be highly up-regulated in some cancers, including non-small cell lung cancers (NSCLC). Using a publically available microarray database
Tingting Li et al.
The Journal of biological chemistry, 289(6), 3775-3785 (2013-12-24)
The altered metabolism in most tumor cells consists of elevated glucose uptake and increased glycolysis even in the presence of high oxygen tension. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an obligatory enzyme in glycolysis. Here, we report that acetylation at lysine 254
Andres E Perez Bay et al.
Nature communications, 7, 11550-11550 (2016-05-18)
The basolateral recycling and transcytotic pathways of epithelial cells were previously defined using markers such as transferrin (TfR) and polymeric IgA (pIgR) receptors. In contrast, our knowledge of the apical recycling pathway remains fragmentary. Here we utilize quantitative live-imaging and
Roberto Puzone et al.
Molecular cancer, 12(1), 97-97 (2013-08-31)
Glycolysis in presence of oxygen with high glucose consumption is known to be the metabolism of choice in many tumors. In lung cancer this phenomenon is routinely exploited in diagnostic PET imaging of fluorodeoxyglucose uptake, but not much is known
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