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GW22756

Sigma-Aldrich

Anti-Endoglin antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
MFCD01094408
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-22756

technique(s)

western blot: suitable

NCBI accession no.

NP_000109.1

UniProt accession no.

P17813

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ENG(2022)

Immunogen

Immunogen Sequence: GI # 4557555, sequence 341-470
Recombinant endoglin

Application

Anti-Endoglin antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Endoglin is a type I transmembrane glycoprotein located on cell surfaces belonging to the transforming growth factor β superfamily. It is commonly referred to as CD105, END, HHT1 and ORW1. It is a part of the TGF β receptor complex, which plays an important role in angiogenesis. CD105 expression correlates with prognosis for several cancers and plays an important role in the pancreatic cancer microenvironment. Tumoral CD105 acts as an independent predictive marker for death risk. Mutation in endoglin causes a vascular defect, hereditary hemorrhagic telangiectasia (HHT1).

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

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Kenji Fujiwara et al.
Pancreas, 42(8), 1283-1290 (2013-12-07)
CD105 expression correlates with prognosis for several cancers. However, its significance in pancreatic cancer is unclear. We analyzed CD105 expression in resected pancreatic cancer tissue and pancreatic cancer cell lines, compared the properties of CD105(+) and CD105(-) cells using quantitative
A Saroufim et al.
British journal of cancer, 110(7), 1778-1784 (2014-03-07)
Angiogenesis is essential for tumour growth and metastasis. There are conflicting reports as to whether microvessel density (MVD) using the endothelial marker CD105 (cluster of differentiation molecule 105) in clear-cell renal cell carcinomas (ccRCC) is associated with prognosis. Recently, CD105
Roselyne Castonguay et al.
The Journal of biological chemistry, 286(34), 30034-30046 (2011-07-09)
Endoglin (CD105), a transmembrane protein of the transforming growth factor β superfamily, plays a crucial role in angiogenesis. Mutations in endoglin result in the vascular defect known as hereditary hemorrhagic telangiectasia (HHT1). The soluble form of endoglin was suggested to

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