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GW22690

Sigma-Aldrich

Anti-CXCL11 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-22690

technique(s)

western blot: suitable

NCBI accession no.

NP_005400.1

UniProt accession no.

O14625

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CXCL11(6373)

Immunogen

Immunogen Sequence: GI # 4885589, sequence 22-85
Recombinant small inducible cytokine B11

Application

Anti-CXCL11 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small cytokine belonging to the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels seen in small intestine, placenta and prostate. It is involved in down-regulating Th1 lymphocyte chemoattraction. CXCL11 is up-regulated in patients with chronic obstructive airways disease.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
039K2064
029K1942

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Joanna C Porter et al.
Journal of immunology (Baltimore, Md. : 1950), 180(3), 1866-1877 (2008-01-23)
The exit of lymphocytes from the interstitium of the lung, across the bronchial epithelium and into the airway lumen, is known as egression, or luminal clearance. Egression is important for immune surveillance and the resolution of inflammation, but the mechanisms
Jennifer H Cox et al.
The Journal of biological chemistry, 283(28), 19389-19399 (2008-04-16)
The CXCR3 chemokine receptor regulates the migration of Th1 lymphocytes and responds to three ligands: CXCL9/MIG, CXCL10/IP-10, and CXCL11/I-TAC. We screened for potential regulation of T cell responses by matrix metalloproteinase (MMP) processing of these important chemokines. The most potent

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