GW22677
Anti-DLG7 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... DLGAP5(9787)
General description
DLGAP5 (discs large homolog-associated protein 5) or DLG7, acts as a mitotic phosphoprotein substrate for Aurora-A. It was recognized 10 years ago, and is a Ser/Thr kinase, which is modulated by cell cycle. It contains a highly conserved domain called guanylate-kinase-associated protein (GKAP) guanylate-kinase-associated protein (GKAP). It is localized to cytoplasm, and is highly expressed in fetal liver. In adults, its predominant expression is in bone marrow, colon, testis and placenta.[1]
Application
Anti-DLG7 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
The expression of discs large-associated protein 5 (DAP-5, also known as DLG7) is hypoxia-controlled and holds prognostic potential in high-risk prostate cancer (CaP). It can act as a novel biomarker for prostate cancer (CaP). Expression of DLGAP5 is regulated by methylation and the up-regulation contributes to hepatocellular carcinoma tumorigenesis by promoting cell proliferation.[1] It is useful for non-invasive test for early detection of bladder cancer and bilharzial bladder cancer.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Weijia Liao et al.
PloS one, 8(12), e80789-e80789 (2013-12-11)
The dysregulation of oncogenes and tumor suppressor genes plays an important role in many cancers, including hepatocellular carcinoma (HCC), which is one of the most common cancers in the world. In a previous microarray experiment, we found that DLGAP5 is
Ming-Ling Chang et al.
PloS one, 6(10), e26323-e26323 (2011-10-25)
Hepatoma up-regulated protein (HURP) is a component of the chromatin-dependent pathway for spindle assembly. We examined the prognostic predictive value of HURP in human hepatocellular carcinoma (HCC). HURP expression was evaluated by immunocytochemistry of fine needle aspirated hepatoma cells in
Sanaa Eissa et al.
Medical oncology (Northwood, London, England), 31(2), 804-804 (2014-01-01)
This study was carried out to assess the efficacy of urinary hepatoma up-regulated protein (HURP) RNA in bladder cancer diagnosis and its relation to bilharziasis. Voided urine samples and blood were collected from 344 consecutive participants: 211 patients diagnosed with
Christian R Gomez et al.
PloS one, 8(12), e82833-e82833 (2013-12-19)
Hypoxia has been associated with malignant progression, metastasis and resistance to therapy. Hence, we studied expression of hypoxia-regulated genes in 100 prostate cancer (CaP) bulk tissues and 71 adjacent benign tissues. We found 24 transcripts significantly overexpressed (p ≤ 0.02).
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