GW22661

Anti-DNMT3A2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: chicken
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: rat, human, mouse
• manufacturer/tradename: Genway 15-288-22661
• technique(s): western blot: suitable
• NCBI accession no.: NP_783328.1
• UniProt accession no.: Q59HC6
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... DNMT3A(1788)

Description

General description

Chicken polyclonal anti-DNMT3A2 antibody reacts with human, rat, and mouse DNA (cytosine-5-)-methyltransferase 3 α 2 methyltransferases.

DNA (cytosine-5-)-methyltransferase 3 α (DNMT3A2) is involved in the epigenetic modification of genes involved in processes that regulate embryonic development, imprinting, and X-chromosome inactivation. For instance DNMT3A promotes the down regulation of Oct-3/4 to prevent reprogramming during early cell differentiation from the pluripotent state. Dysfunctional DNMT3A have been associated with incidence of acute myeloid leukemia (AML).

Immunogen

Immunogen Sequence: GI # 28559069, sequence 1-300

Recombinant DNA cytosine methyltransferase 3 α isoform a

Application

Chicken polyclonal anti-DNMT3A2 antibody is used to tag DNA (cytosine-5-)-methyltransferase 3 α 2 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of DNA (cytosine-5-)-methyltransferase 3 α 2 in post-translational (epigenetic) gene regulation involving the processes of embryonic development, imprinting, and X-chromosome inactivation.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)