GW22608
Anti-WAS antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-22608
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... WAS(7454)
Immunogen
Immunogen Sequence: GI # 4507909, sequence 313-425
Recombinant wiskott-Aldrich syndrome protein
Application
Anti-WAS antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Wiskott-Aldrich syndrome (WAS) is a rare X-linked recessive disease and is caused by mutations in Wiskott-Aldrich Syndrome Protein (WASP). It is characterized by eczema, thrombocytopenia (low platelet count), immune deficiency, a higher susceptibility to develop tumors and bloody diarrhea (secondary to the thrombocytopenia). WAS is also involved in defects in cell adhesion underpinning cytotoxicity and disease pathogenesis. It regulates the cytoskeleton in hematopoietic cells.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Maria Carmina Castiello et al.
Journal of autoimmunity, 50, 42-50 (2013-12-29)
Wiskott-Aldrich Syndrome protein (WASp) regulates the cytoskeleton in hematopoietic cells and mutations in its gene cause the Wiskott-Aldrich Syndrome (WAS), a primary immunodeficiency with microthrombocytopenia, eczema and a higher susceptibility to develop tumors. Autoimmune manifestations, frequently observed in WAS patients
Shulian Zhang et al.
Fetal and pediatric pathology, 32(4), 312-315 (2013-01-11)
Wiskott-Aldrich syndrome (WAS) is a rare X-linked recessive disease characterized by eczema, thrombocytopenia and immune deficiency. WAS gene mutations impair WAS protein function which cause WAS. The WAS-related disorders of X-linked thrombocytopenia (XLT) and X-linked congenital neutropenia (XLN) may have
Neeraj Jain et al.
Biochimica et biophysica acta, 1842(4), 623-634 (2014-01-21)
Wiskott-Aldrich Syndrome (WAS) is caused by mutations in Wiskott-Aldrich Syndrome Protein (WASP) and majority of the mutations are found in the WASP Homology 1 (WH1) domain which mediates interaction with WIP (WASP Interacting Protein), a WASP chaperone. Two point mutations
Anne-Caroline Chany et al.
Journal of medicinal chemistry, 57(17), 7382-7395 (2014-08-27)
Mycolactone is a complex macrolide toxin produced by Mycobacterium ulcerans, the causative agent of skin lesions called Buruli ulcers. Mycolactone-mediated activation of neural (N) Wiskott-Aldrich syndrome proteins (WASP) induces defects in cell adhesion underpinning cytotoxicity and disease pathogenesis. We describe
Sudha Kumari et al.
The EMBO journal, 39(5), e102783-e102783 (2020-01-03)
When migratory T cells encounter antigen-presenting cells (APCs), they arrest and form radially symmetric, stable intercellular junctions termed immunological synapses which facilitate exchange of crucial biochemical information and are critical for T-cell immunity. While the cellular processes underlying synapse formation
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