GW22594
Anti-DUSP12 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
western blot: suitable
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... DUSP12(11266)
General description
DUSP12 (dual specificity phosphatase) gene is localized to human chromosome 1q21-q22. Its C-terminal contains a non-catalytic domain, which is rich in cysteine and acts as a zinc finger domain. It is an atypical DUSP member, which is recognized as a phosphatase with pro-survival attributes. It is evolutionarily conserved. Its DUSP catalytic domain is present at its N-terminal.
The previously assigned protein identifier Q5VXA8 has been merged into Q9UNI6. Full details can be found on the UniProt database.
The previously assigned protein identifier Q5VXA8 has been merged into Q9UNI6. Full details can be found on the UniProt database.
Immunogen
Immunogen Sequence: GI # 6005956, sequence 1-340
Recombinant dual specificity phosphatase 12
Application
Anti-DUSP12 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Dual specificity protein phosphatase 12 (DSUP12) is a novel cell survival phosphatase. DUSP12 is an evolutionary conserved phosphatase containing a unique zinc-binding domain. Its expression affects cell cycle progression. Overexpression of the gene increases cell motility and resistance to apoptosis. Overexpression also causes a significant increase in polyploidy and in the G 2/M cell population, with a subsequent decrease in the G 0/G 1 population. It promotes increased expression of the c-met proto-oncogene and collagen, and laminin receptor intergrin α 1 (itgα1), which is implicated in metastasis. DUSP12 is oncologically relevant and could be used therapeutically for targeted oncogenes. The enzyme plays a role in cell survival and ribosome biogenesis and protects cells from oxidative stress.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Priya R Sharda et al.
The Biochemical journal, 418(2), 391-401 (2008-11-01)
hYVH1 [human orthologue of YVH1 (yeast VH1-related phosphatase)] is an atypical dual-specificity phosphatase that is widely conserved throughout evolution. Deletion studies in yeast have suggested a role for this phosphatase in regulating cell growth. However, the role of the human
M Muda et al.
The Journal of biological chemistry, 274(34), 23991-23995 (1999-08-14)
A human orthologue of the Saccharomyces cerevisiae YVH1 protein-tyrosine phosphatase is able to rescue the slow growth defect caused by the disruption of the S. cerevisiae YVH1 gene. The human YVH1 gene is located on chromosome 1q21-q22, which falls in
Anna Kozarova et al.
Cell cycle (Georgetown, Tex.), 10(10), 1669-1678 (2011-04-28)
The dual-specificity phosphatase hYVH1 (DUSP12) is an evolutionary conserved phosphatase that also contains a unique zinc-binding domain. Recent evidence suggests that this enzyme plays a role in cell survival and ribosome biogenesis. Here, we report that hYVH1 expression also affects
Christopher A Bonham et al.
The Journal of biological chemistry, 284(34), 22853-22864 (2009-07-02)
YVH1 was one of the first eukaryotic dual specificity phosphatases cloned, and orthologues poses a unique C-terminal zinc-coordinating domain in addition to a cysteine-based phosphatase domain. Our recent results revealed that human YVH1 (hYVH1) protects cells from oxidative stress. This
Erica L Cain et al.
PloS one, 6(4), e18677-e18677 (2011-05-11)
Analysis of chromosomal rearrangements within primary tumors has been influential in the identification of novel oncogenes. Identification of the "driver" gene(s) within cancer-derived amplicons is, however, hampered by the fact that most amplicons contain many gene products. Amplification of 1q21-1q23
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