GW22538F
Anti-GRB2 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human, rat
manufacturer/tradename
Genway 15-288-22538F
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GRB2(2885)
General description
GRB2 (growth factor receptor-bound protein 2) is an adaptor protein, which is expressed ubiquitously. It is composed of two SH3 domains and one SH2 domain. The SH3 domains are present at the N- and C-termini, and are intervened by SH2 domain. It exists as a heterodimeric protein.
Immunogen
Immunogen Sequence: GI # 4504111, sequence 1-217
Recombinant growth factor receptor-bound protein 2 isoform 1
application
Anti-GRB2 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Growth factor receptor-bound protein 2 (GRB2) is involved in signal transduction/cell communication. GRB2 controls fibroblast growth factor receptor 2 (FGFR2) signaling by regulating receptor kinase and SH2 domain-containing protein tyrosine phosphatase 2 (Shp2) phosphatase activities in the absence of extracellular stimulation. The protein is involved in the activation of the Ras signaling pathway. It helps in the regulation of Receptor tyrosine kinases (RTKs) signaling. GRB2 is associated with tyrosine-phosphorylated epidermal growth factor receptors (EGFRs) and platelet-derived growth factor receptors (PDGFRs) through its SH2 domain. It plays a crucial role in a highly conserved mechanism for growth factor control of ras signaling.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Li-Yan Li et al.
International journal of clinical and experimental pathology, 7(6), 3132-3140 (2014-07-18)
The adapter protein growth factor receptor-bound 2 (GRB2) is essential for various basic cellular functions by mediating the regulation of receptor tyrosine kinase (RTK) signaling, however, little is known about GRB2 expression in esophageal squamous cell carcinoma (ESCC). We sought
Artur A Belov et al.
Science signaling, 5(249), pe49-pe49 (2012-11-08)
Receptor tyrosine kinases (RTKs) exhibit basal tyrosine phosphorylation and activity in the absence of ligand stimulation, which has been attributed to the "leaky" nature of tyrosine kinase autoinhibition and stochastic collisions of receptors in the membrane bilayer. This basal phosphorylation
Zamal Ahmed et al.
The Journal of cell biology, 200(4), 493-504 (2013-02-20)
Constitutive receptor tyrosine kinase phosphorylation requires regulation of kinase and phosphatase activity to prevent aberrant signal transduction. A dynamic mechanism is described here in which the adaptor protein, growth factor receptor-bound protein 2 (Grb2), controls fibroblast growth factor receptor 2
Nico J de Mol et al.
Biochimica et biophysica acta, 1834(2), 524-535 (2012-11-20)
The Grb2 adapter protein is involved in the activation of the Ras signaling pathway. It recruits the Sos protein by binding of its two SH3 domains to Sos polyproline sequences. We observed that the binding of Grb2 to a bivalent
E J Lowenstein et al.
Cell, 70(3), 431-442 (1992-08-07)
A cDNA clone encoding a novel, widely expressed protein (called growth factor receptor-bound protein 2 or GRB2) containing one src homology 2 (SH2) domain and two SH3 domains was isolated. Immunoblotting experiments indicate that GRB2 associates with tyrosine-phosphorylated epidermal growth
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