Anti-Interleukin-18 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Interleukin-18 (IL18, also known as interferon-γ inducing factor) is a protein encoded by the IL18 gene in humans and is mapped to chromosome 11q22.2-q22.3. It is a well-known major proinflammatory cytokine with broad biological effects. Major function of IL-18 involves the enhancement of T cell and natural killer cell cytotoxicity. It is an inflammatory cytokine and plays an important role in autoimmune disease by inducing interferon-γ secretion. IL18 may contribute to SLE (systemic lupus erythematosus) activity.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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The Egyptian journal of immunology, 21(1), 1-12 (2014-09-11)
Systemic lupus erythematosus (SLE) is a multisystem autoimmune connective tissue disorder characterized by loss of self-tolerance causing immune-mediated tissue destruction and various clinical presentations Interleukin-18 (IL-18) is a proinflammatory cytokine that plays an important role in chronic inflammation and autoimmune
Revista da Sociedade Brasileira de Medicina Tropical, 47(2), 137-142 (2014-05-28)
Interleukin (IL)-18 is a well-known major proinflammatory cytokine with broad biological effects. The major immunomodulatory functions of IL-18 include enhancing T cell and natural killer cell cytotoxicity. Serum levels of this cytokine were shown to increase in chronic hepatitis C
The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci.
Interleukin-18 (IL-18) is an inflammatory cytokine that plays an important role in autoimmune disease by inducing interferon-γ secretion. Considering the abnormal serum concentration of IL-18 in primary immune thrombocytopenia (ITP) patients and the regulated effect of IL-18 gene polymorphisms on
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