GW22444
Anti-Importin α2 subunit antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, mouse, human
manufacturer/tradename
Genway 15-288-22444
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KPNA2(3838)
General description
Importin α2, also called KPNA2 (karyopherin α2), is an adaptor protein, which belongs to a family of nucleocytoplasmic transport proteins called karyopherin α (KPNA). This family contains around seven members, and KPNA2 is expressed in epidermal keratinocytes and undifferentiated embryonic cells.
Application
Anti-Importin a2 subunit antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Importin subunit α-2 interacts with proteins associated with mRNA processing, ribonucleoprotein complex biogenesis, chromatin modification and transcription. KPNA2 expression is induced in tumor cells and in various proliferative disorders of the skin such as psoriasis, Bowen′s disease, actinic keratosis, squamous cell carcinoma, Paget′s disease, Merkel cell carcinoma, and mycosis fungoides. KPNA2 may act as an important promoter of ribosomal RNA and protein synthesis in tumor cells. Overexpression of KPNA2 is linked to poor prognosis in a variety of malignancies. KPNA2 functions as an adaptor by transporting several proteins to the nucleus. It might be a useful prognostic marker and an effective therapeutic target for gastric cancer (GC).
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Katharina Grupp et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(1), 96-106 (2013-07-28)
Increased levels of karyopherin α2 (KPNA2) expression have been described to be linked to poor prognosis in a variety of malignancies. This study was undertaken to evaluate the clinical impact of KPNA2 expression and its association with key genomic alterations
Noriko Umegaki-Arao et al.
PloS one, 8(10), e76416-e76416 (2013-10-08)
Karyopherin proteins mediate nucleocytoplasmic trafficking and are critical for protein and RNA subcellular localization. Recent studies suggest KPNA2 expression is induced in tumor cells and is strongly associated with prognosis, although the precise roles and mechanisms of KPNA2 overexpression in
A T Alshareeda et al.
British journal of cancer, 112(12), 1929-1937 (2015-05-20)
It is recognised that modulations of the nuclear import of macromolecules have a role in changing cellular phenotypes and carcinogenesis. We and others have noticed that aberrant subcellular localisation of DNA damage response (DDR) proteins in breast cancer (BC) is
Chen Li et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 34(2), 1021-1026 (2013-01-04)
This study aims to investigate the expression and significance of KPNA2 in human gastric adenocarcinoma progression and prognosis. Using immunohistochemistry and real-time reverse transcriptase polymerase chain reaction assay, we identified abnormally elevated expression of KPNA2 in gastric adenocarcinoma tissues compared
Bolag Altan et al.
Carcinogenesis, 34(10), 2314-2321 (2013-06-12)
Karyopherin-α2 (KPNA2) functions as an adaptor that transports several proteins to the nucleus. We investigated the clinical and functional significance of KPNA2 in gastric cancer (GC). Immunohistochemistry was performed to examine KPNA2 expression in primary GC and metastatic lymph nodes.
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