Anti-RSU1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Ras suppressor protein 1 is a protein that in humans is encoded by the RSU1 gene and is mapped to human chromosome 10p13. Its expression inhibited the tumorigenesis of a glioblastoma cell line and may inhibit growth regulation in tumors. Rsu-1 may help in inhibiting cell migration by stabilizing the IPP adhesion complex and that Ras activation perturbs this inhibitory function by modulating both Rsu-1 splicing and association of full-length Rsu-1 with IPP. It links the Ras pathway with the IPP complex and the perturbations of cell attachment-dependent signaling that occur in the malignant process.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Journal of neuro-oncology, 60(3), 201-211 (2003-01-04)
Previous studies demonstrated that the Ras suppressor, RSU-1, localizes to human chromosome 10p13, a region frequently deleted in high grade gliomas, and that RSU-1 expression inhibited the tumorigenesis of a glioblastoma cell line. We have now examined RNA from human
European journal of cell biology, 87(8-9), 721-734 (2008-04-26)
The link between Ras transformation and enhanced cell migration due to altered integrin signaling is well established in tumorigenesis, however there remain gaps in our understanding of its mechanism. The Ras suppressor, Rsu-1, has recently been linked to the IPP
Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10.
T Tsuda et al.
Genomics, 18(2), 461-462 (1993-11-01)
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