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GW22400

Sigma-Aldrich

Anti-CLIC3 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat, mouse

manufacturer/tradename

Genway 15-288-22400

technique(s)

western blot: suitable

NCBI accession no.

NP_004660.2

UniProt accession no.

O95833

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CLIC3(9022)

Immunogen

Immunogen Sequence: GI # 40288290, sequence 29-236
Recombinant chloride intracellular channel 3

Application

Anti-CLIC3 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Chloride intracellular channel protein 3 is a protein encoded by the CLIC3 gene in humans. The protein is a chloride channel and is a new member of the human CLIC family. CLIC3 may play a role in the regulation of cell growth. It may also play an important role in abnormal placental function associated with the human pregnancy disorders FGR and PE. CLIC3 may help in facilitating chloride ion movement and the regulation of cellular processes associated with the movement of chloride in the placental and fetal membrane cells, in which it is expressed.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
118K1905
039K1748
049K0521
029K1959

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P Murthi et al.
Placenta, 33(9), 741-744 (2012-07-17)
Chloride intracellular channel (CLIC) proteins constitute a subgroup of the glutathione-S-transferase (GSTs) superfamily. In humans, the CLIC family of proteins consists of six members, designated CLIC 1-6, which have a conserved C-terminal 240 residue module and one major transmembrane domain.
Z Qian et al.
The Journal of biological chemistry, 274(3), 1621-1627 (1999-01-09)
ERK7, a member of the mitogen-activated protein kinase family, has a carboxyl-terminal tail that is required for ERK7 activation, cellular localization, and its ability to inhibit DNA synthesis. To identify proteins that interact with ERK7, we utilized a yeast two-hybrid
T T Money et al.
Placenta, 28(5-6), 429-436 (2006-10-10)
Chloride channels regulate the movement of a major cellular anion and are involved in fundamental processes that are critical for cell viability. Regulation of intracellular chloride is achieved by multiple classes of channel proteins. One class of putative channels are

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