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GW22398F

Sigma-Aldrich

Anti-GCA antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-22398F

technique(s)

western blot: suitable

NCBI accession no.

P28676

UniProt accession no.

P28676

shipped in

wet ice

Storage temp.

−20°C

Gene Information

human ... GCA(25801)

Immunogen

Immunogen Sequence: GI # 1170014, sequence 1-217
Recombinant grancalcin

Application

Anti-GCA antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Grancalcin is a protein encoded by the GCA gene in humans and is a member of the EF-hand family of calcium-binding proteins called PEF proteins. It is a EF-hand Ca2+-binding protein (28kDa) particularly abundant in neutrophils and monocytes, with relatively small amounts in lymphocytes. Grancalcin consists of four EF-hand calcium-binding motifs and exhibits strong homology to sorcin, one of two proteins overexpressed in multidrug-resistant cells.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
029K1662
049K0552

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A Boyhan et al.
The Journal of biological chemistry, 267(5), 2928-2933 (1992-02-15)
A novel EF-hand Ca(2+)-binding protein we have called grancalcin has been identified and characterized. This protein is particularly abundant in neutrophils and monocytes, with relatively small amounts in lymphocytes. The cDNA for this protein has been cloned and sequenced. The
J Jia et al.
Acta crystallographica. Section D, Biological crystallography, 57(Pt 12), 1843-1849 (2001-11-22)
Grancalcin is a cytosolic Ca(2+)-binding protein originally identified in human neutrophils. It belongs to a new class of EF-hand proteins, called PEF proteins, which contain five EF-hand motifs. At the N-terminus of grancalcin there is a approximately 50 residue-long segment
C G Teahan et al.
The Biochemical journal, 286 ( Pt 2), 549-554 (1992-09-01)
A novel 28 kDa protein, which we have named 'grancalcin', has been identified in human neutrophils. The protein was isolated from the cytosol and found to be a homodimer, with an apparent molecular mass of 55 kDa on gel filtration.

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