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GW22386

Sigma-Aldrich

Anti-MORF4 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse

manufacturer/tradename

Genway 15-288-22386

technique(s)

western blot: suitable

NCBI accession no.

NP_006783.2

UniProt accession no.

Q9Y690

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MORF4(10934)

Immunogen

Immunogen Sequence: GI # 6996928, sequence 1-235

Application

Anti-MORF4 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Morf4 is a member of a family of seven genes and is mapped on chromosomes 15 (4q33-q34.1). It is a positive regulators of cell division and interact with histone deacetylases and acetyltransferases. Morf4 functions in regulation of chromatin dynamics. The proteins that escapes degradation in the cytoplasm, is transported to the nucleus where it is functional.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

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Steven D Bryce et al.
Neoplasia (New York, N.Y.), 4(6), 544-550 (2002-10-31)
Human chromosome 4 was previously shown to elicit features of senescence when introduced into cell lines that map to complementation group B for senescence, including HeLa cells. Subsequently, a DNA segment encoding the pseudogene Mortality Factor 4 (MORF4) was shown
Meizhen Chen et al.
Annals of the New York Academy of Sciences, 1197, 134-141 (2010-06-12)
Cellular senescence is the dominant phenotype over immortality. In our studies to identify senescence-related genes, we cloned Morf4, which induced senescence in a subset of tumor cells. Morf4 is a member of a family of seven genes, and Morf-related genes
Kaoru Tominaga et al.
Experimental cell research, 316(1), 92-102 (2009-09-23)
After undergoing several rounds of divisions normal human fibroblasts enter a terminally non-dividing state referred to as cellular or replicative senescence. We cloned MORF4 (mortality factor on human chromosome 4), as a cellular senescence inducing gene that caused immortal cells

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