Anti-MAD2L1BP antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
MAD2L1-binding protein is a protein encoded by the MAD2L1BP gene in humans. MAD2 is a key component of the spindle checkpoint and is implicated in silencing the spindle assembly checkpoint after all kinetochores are attached to spindles. MAD2L1 overexpression in cells arrested by the spindle checkpoint causes premature destruction of securin and allows exit from mitosis without chromosome segregation. Its depletion induces cell death following a transient delay in the onset of anaphase. It interacts with the spindle checkpoint and coordinates cell cycle events in late mitosis.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. It binds to human p55CDC and prevents it from promoting destruction of an anaphase inhibitor, securin.
The Journal of biological chemistry, 287(25), 21561-21569 (2012-05-01)
Antimitotic spindle poisons are among the most important chemotherapeutic agents available. However, precocious mitotic exit by mitotic slippage limits the cytotoxicity of spindle poisons. The MAD2-binding protein p31(comet) is implicated in silencing the spindle assembly checkpoint after all kinetochores are
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