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GW22364F

Sigma-Aldrich

Anti-PIN1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-22364F

technique(s)

western blot: suitable

NCBI accession no.

NP_006212.1

UniProt accession no.

Q13526

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PIN1(5300)

Immunogen

Immunogen Sequence: GI # 5453898, sequence 1-163
Recombinant protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1

Application

Anti-PIN1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme encoded by the PIN1 gene in humans and belongs to parvulin PPIase family. It is an essential PPIase (peptidyl-prolyl cis/trans isomerase) that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Pin1 regulates proteins involved in cell proliferation and pluripotency or cellular invasion. It is overexpressed in several human cancers and contributes to tumorigenesis. Pin1 plays a crutial role in cell transformation and oncogenesis. It is necessary for the regulation of the enzyme as well.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
039K1776
029K2142

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Yan-Mei Zhu et al.
Asian Pacific journal of cancer prevention : APJCP, 14(10), 5965-5972 (2013-12-03)
PIN1 is one member of the parvulin PPIase family. By controlling Pro-directed phosphorylation, PIN1 plays an important role in cell transformation and oncogenesis. There are many polymorphisms in the PIN1 gene, including rs2233678 and rs2233679 affecting the PIN1 promoter. Recently
Justine Marsolier et al.
Medecine sciences : M/S, 30(8-9), 772-778 (2014-09-02)
Post-translational modifications are critical to modulate protein function. A post-translational mechanism, peptidyl prolyl cis-trans isomerisation, plays a key role in protein regulation. Pin1 is a ubiquitous peptidyl prolyl cis-trans isomerase conserved from Archae to Human. This enzyme binds and isomerizes
Arghya Barman et al.
Biochemistry, 53(23), 3839-3850 (2014-05-21)
Enzymes catalyze a plethora of chemical reactions that are tightly regulated and intricately coupled in biology. Catalysis of phosphorylation-dependent cis-trans isomerization of peptidyl-prolyl bonds, which act as conformational switches in regulating many post-phosphorylation processes, is considered to be one of
K P Lu et al.
Nature, 380(6574), 544-547 (1996-04-11)
The NIMA kinase is essential for progression through mitosis in Aspergillus nidulans, and there is evidence for a similar pathway in other eukaryotic cells. Here we describe the human protein Pin1, a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA.

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