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GW22361F

Sigma-Aldrich

Anti-UCK2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

manufacturer/tradename

Genway 15-288-22361F

technique(s)

western blot: suitable

NCBI accession no.

NP_036606.2

UniProt accession no.

Q9BZX2

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... UCK2(7371)

Immunogen

Immunogen Sequence: GI # 18699734, sequence 1-261
Recombinant uridine-cytidine kinase 2

Biochem/physiol Actions

Uridine-cytidine kinase 2 is an enzyme encoded by the UCK2 gene in humans. It is normally expressed in human placenta, but is overexpressed in certain cancer cells and is also responsible for activating a class of antitumor prodrugs. UCK2 is responsible for the phosphorylation and activation of the antitumor 3′-ethynyl nucleosides. It play an important role in activating anti-tumour pro-drugs in human cancer cells.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
039K1887
029K2157

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Adam J T Smith et al.
Organic & biomolecular chemistry, 7(13), 2716-2724 (2009-06-18)
The mechanisms of enzyme-catalyzed phosphate transfer and hydrolysis reactions are of great interest due to their importance and abundance in biochemistry. The reaction may proceed in a stepwise fashion, with either a pentavalent phosphorane or a metaphosphate anion intermediate, or
Daigo Murata et al.
Drug metabolism and disposition: the biological fate of chemicals, 32(10), 1178-1182 (2004-07-29)
The antitumor 3'-ethynyl nucleosides, 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine (ECyd) and 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine (EUrd), are potent inhibitors of RNA polymerases and show excellent antitumor activity against various human solid tumors in xenograft models. ECyd is being investigated in phase I clinical trials as a novel
Nobuo N Suzuki et al.
Acta crystallographica. Section D, Biological crystallography, 59(Pt 8), 1477-1478 (2003-07-24)
Uridine-cytidine kinase (UCK), which converts uridine and cytidine to their corresponding monophosphates, is a rate-limiting enzyme involved in the salvage pathway of pyrimidine-nucleotide biosynthesis. Two members of human UCK, named UCK1 and UCK2, were cloned recently and UCK2 was reported

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