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GW22346

Sigma-Aldrich

Anti-BCAS2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, rat, human

manufacturer/tradename

Genway 15-288-22346

technique(s)

western blot: suitable

NCBI accession no.

NP_005863.1

UniProt accession no.

O75934

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BCAS2(10286)

Immunogen

Immunogen Sequence: GI # 5031653, sequence 1-225
Recombinant breast carcinoma amplified sequence 2

Application

Anti-BCAS2 antibody produced in chicken is suitable western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Pre-mRNA-splicing factor SPF27 is a protein encoded by the BCAS2 gene in humans and is mapped to chromosome 1p13.3-21 region. It codes for a nuclear protein. BCAS2 is a novel gene up-regulated by amplification in human breast cancer cell lines. It acts as a transcriptional coactivator of estrogen receptor. It directly interacts with p53 to reduce p53 transcriptional activity and consistently decreases p53 protein in the absence of DNA damage. BCAS2 is a small nuclear protein (26kDa) and a novel negative regulator of p53. It is a potential molecular target for cancer therapy.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

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Nicolai Maass et al.
Cancer letters, 185(2), 219-223 (2002-08-10)
BCAS2 is a novel gene isolated from breast cancer cell line by differential display technique. Previously we reported that BCAS2 gene is localized on chromosome 1p13.3-21 and is up-regulated by gene amplification in breast cancer cell lines MCF-7 and BT-20.
K Nagasaki et al.
Cancer letters, 140(1-2), 219-226 (1999-07-14)
Screening for differentially expressed genes in cancer cell lines by the RNA differential display (DD) technique identified a novel mRNA that encodes a 26-kDa protein and is up-regulated in MCF-7 and BT-20 breast cancer cells. The predicted amino acid sequence
Ping-Chang Kuo et al.
Cancer research, 69(23), 8877-8885 (2009-11-12)
Breast cancer amplified sequence 2 (BCAS2) was reported previously as a transcriptional coactivator of estrogen receptor. Here, we report that BCAS2 directly interacts with p53 to reduce p53 transcriptional activity by mildly but consistently decreasing p53 protein in the absence

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