GW22317B
Anti-SLP-2 (ab2) antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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50 μG
$418.00
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
chicken
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human, rat
manufacturer/tradename
Genway 15-288-22317B
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLP-2(30968)
General description
The previously assigned protein identifier Q53G29 has been merged into Q9UJZ1. Full details can be found on the UniProt database.
Application
Anti-SLP-2 (ab2) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Stomatin-like protein 2 (STOML2) is a member of the stomatin superfamily and is a widely expressed mitochondrial inner membrane protein. It acts as an oncogenic-related protein and is found to be up-regulated in multi-cancers.[1] STOML2 has a role and clinical significance in gastric adenocarcinoma and gallbladder cancer (GBC). Increased expression of STOML2 may lead to unfavorable prognosis for gastric adenocarcinoma patients. STOML2 may play an important role in human GBC tumorigenesis and may serve as a novel prognostic marker in human GBC. It interacts with prohibitin-1 and -2 and binds to the mitochondrial membrane phospholipid cardiolipin. The up-regulation of this gene expression increases cardiolipin content, the formation of metabolically active mitochondrial membranes and also induces mitochondrial biogenesis.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Xiao-Hong Li et al.
Medical oncology (Northwood, London, England), 31(1), 763-763 (2013-11-22)
Stomatin-like protein 2 (STOML2), a member of the stomatin, has been reported to be upregulated in several human cancers. However, its role and clinical significance in gastric adenocarcinoma remains unclear to date. The purpose of this retrospective study was to
Wei-Xin Wang et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(1), 419-423 (2013-08-07)
Several studies have indicated that overexpression of stomatin-like protein 2 (SLP-2) has been identified in several types of cancer. However, its role and clinical relevance in gallbladder cancer (GBC) is unknown. The purpose of this study was to reveal the
Zhibing Qiu et al.
Journal of cellular biochemistry (2018-10-12)
Previous studies have shown that stomatin-like protein-2 (SLP-2) could regulate mitochondrial biogenesis and function. The study was designed to explore the contribution of SLP-2 to the myocardial ischemia and reperfusion (I/R) injury. Anesthetized rats were treated with SLP-2 and subjected
Darah A Christie et al.
Molecular and cellular biology, 31(18), 3845-3856 (2011-07-13)
Stomatin-like protein 2 (SLP-2) is a widely expressed mitochondrial inner membrane protein of unknown function. Here we show that human SLP-2 interacts with prohibitin-1 and -2 and binds to the mitochondrial membrane phospholipid cardiolipin. Upregulation of SLP-2 expression increases cardiolipin
Wenfeng Cao et al.
PloS one, 8(5), e63890-e63890 (2013-05-15)
Stomatin-like protein 2 (SLP-2), a member of the Stomatin superfamily, has been identified as an oncogenic-related protein and found to be up-regulated in multi-cancers. Nonetheless, the expression pattern and regulation of SLP-2 in human esophageal squamous cell carcinoma (ESCC) remain
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