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GW22314F

Sigma-Aldrich

Anti-LSM4 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

manufacturer/tradename

Genway 15-288-22314F

technique(s)

indirect ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... LSM4(25804)

Immunogen

Immunogen Sequence: GI # 6912486, sequence 1-139
Recombinant U6 snRNA-associated Sm-like protein 4

Application

Anti-LSM4 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

U6 snRNA-associated Sm-like protein LSm4 is a protein that, in humans, is encoded by the LSM4 gene. Over-expression of LSm4 affects the translocation of ICln (it is a ubiquitous, multifunctional protein with functions in cell volume regulation and RNA processing) to the cell membrane. It inhibits the activation kinetics and current density of IClswell. LSm4 acts in RNA processing and also as a co-factor in cell volume regulation.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Daniel Schraivogel et al.
Nucleic acids research, 43(15), 7447-7461 (2015-07-15)
MicroRNAs (miRNAs) guide Argonaute (Ago) proteins to distinct target mRNAs leading to translational repression and mRNA decay. Ago proteins interact with a member of the GW protein family, referred to as TNRC6A-C in mammals, which coordinate downstream gene-silencing processes. The
Rosaria Gandini et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 22(5-6), 579-590 (2008-12-18)
ICln is a ubiquitous, multifunctional protein with functions in cell volume regulation and RNA processing, and is thus part of an intricate protein network critically involved in the homoeostasis of cells. To better understand this vital protein network in health
Souvik Ghosh et al.
The EMBO journal, 39(18), e103922-e103922 (2020-08-20)
Translational readthrough, i.e., elongation of polypeptide chains beyond the stop codon, was initially reported for viral RNA, but later found also on eukaryotic transcripts, resulting in proteome diversification and protein-level modulation. Here, we report that AGO1x, an evolutionarily conserved translational

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