Recombinant regulator of G-protein signalling 19 interacting protein 1 isoform 1
Application
Anti-GIPC1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
GIPC PDZ domain containing family, member 1 (GIPC1) is a protein encoded by the GIPC1 gene in humans. The mammalian GIPC1 consists of a central PDZ domain and a C-terminal acyl carrier protein (ACP) domain. It is an essential adaptor protein of receptors that plays an important role in cancer progression and therapy resistance. The GIPC1 cytoplasmic scaffold protein interacts with numerous receptor signaling complexes and plays a role in tumorigenesis. It is highly expressed in a number of human malignancies that include breast, ovarian, gastric and pancreatic cancers. GIPC1 inhibition may be a new target for therapeutic development for the treatment of human cancers. It is a breast cancer-associated immunogenic antigen that is overexpressed in breast cancer.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Proceedings of the National Academy of Sciences of the United States of America, 95(21), 12340-12345 (1998-10-15)
We have identified a mammalian protein called GIPC (for GAIP interacting protein, C terminus), which has a central PDZ domain and a C-terminal acyl carrier protein (ACP) domain. The PDZ domain of GIPC specifically interacts with RGS-GAIP, a GTPase-activating protein
GIPC1 is a cytoplasmic scaffold protein that interacts with numerous receptor signaling complexes, and emerging evidence suggests that it plays a role in tumorigenesis. GIPC1 is highly expressed in a number of human malignancies, including breast, ovarian, gastric, and pancreatic
We have been studying the native autoimmune response to cancer through the isolation of human monoclonal antibodies that are cancer specific from cancer patients. To facilitate this work we previously developed a fusion partner cell line for human lymphocytes, MFP-2
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 188(12), 1125-1132 (2012-11-07)
Studies have shown that GIPC1/Synectin is an essential adaptor protein of receptors that play an important role in cancer progression and therapy resistance. This is the first study to explore the role of GIPC1/Synectin in radioresistance of prostate cancer and
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
