GW22307B
Anti-ADFP (ab2) antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse
manufacturer/tradename
Genway 15-288-22307B
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ADFP(123)
General description
ADFP (adipose differentiation-related protein) is a mammalian lipid droplet protein, which coats lipid droplet surfaces. It is however absent from mature white adipocytes. It is also called perilipin 2 (PLIN2), and is a member of the PAT (perilipin, adipophilin, and the tail-interacting protein 47kDa) family of proteins, which includes five members. It has a predominant expression in skeletal muscles, in type I fibres.
Immunogen
Immunogen Sequence: GI # 34577059, sequence 241-437
Recombinant adipose differentiation-related protein
Application
Anti-ADFP (ab2) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Adipose differentiation-related protein (ADFP) plays a novel role in the regulation of macrophage autophagy during lipopolysaccharide (LPS) stimulation. ADFP is the most abundant lipid droplet (LD)-associated protein found in non-adipose tissue and its expression correlates with intracellular lipid accumulation. Its polymorphism may affect its function and influence the development of metabolic and cardiovascular diseases. It has been observed that prolonged endurance-type exercise training increases the expression of ADFP leading to increases in intramuscular triglyceride (IMTG) content in a type I muscle fiber-type specific manner in type 2 diabetes patients.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Joëlle Magné et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(8), 3090-3099 (2013-04-23)
Perilipin 2 (PLIN2) is the most abundant lipid droplet (LD)-associated protein in nonadipose tissue, and its expression correlates with intracellular lipid accumulation. Here we identified a missense polymorphism, Ser251Pro, that has major effect on protein structure and function, along with
Maria Conte et al.
PloS one, 8(8), e73709-e73709 (2013-08-27)
Human aging is associated with a progressive loss of muscle mass and strength and a concomitant fat accumulation in form of inter-muscular adipose tissue, causing skeletal muscle function decline and immobilization. Fat accumulation can also occur as intra-muscular triglycerides (IMTG)
Xuyang Feng et al.
Lipids in health and disease, 13, 10-10 (2014-01-11)
Autophagy is an essential process for breaking down macromolecules and aged/damaged cellular organelles to maintain cellular energy balance and cellular nutritional status. The idea that autophagy regulates lipid metabolism is an emerging concept with important implications for atherosclerosis. However, the
Arthur Sletten et al.
Biochemical and biophysical research communications, 452(3), 422-427 (2014-08-31)
All eukaryotic organisms store excess lipid in intracellular lipid droplets. These dynamic structures are associated with and regulated by numerous proteins. Perilipin 2, an abundant protein on most lipid droplets, promotes neutral lipid accumulation in lipid droplets. However, the mechanism
C S Shaw et al.
American journal of physiology. Endocrinology and metabolism, 303(9), E1158-E1165 (2012-09-06)
The aim of the present study was to investigate changes in intramuscular triglyceride (IMTG) content and perilipin 2 expression in skeletal muscle tissue following 6 mo of endurance-type exercise training in type 2 diabetes patients. Ten obese male type 2
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
