GW22299F
Anti-M6PRBP1 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-22299F
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... M6PRBP1(10226)
General description
M6PRBP1 (Mannose-6-phosphate receptor binding protein 1) is a lipid droplet-associated protein, which is highly expressed, especially in adipocytes. It is also called perilipin 3 (PLIN3), and is a member of the PAT (perilipin, adipophilin, and the tail-interacting protein 47kDa) family of proteins, which includes five members. The N-terminal of this protein contains PAT-1 domain, and the C-terminal contains the PAT-2 domain. Both these domains are highly conserved regions.
Immunogen
Immunogen Sequence: GI # 20127486, sequence 1-434
Recombinant mannose 6 phosphate receptor binding protein 1
Application
Anti-M6PRBP1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) has apolipoprotein-like properties and reorganizes liposomes into small lipid discs and plays a function in the biogenesis of cytosolic lipid droplets (LD). M6PRBP1 has a pivotal role in cytosolic lipid droplets (LD)-biogenesis in HL-60-derived neutrophils. It is associated with the synthesis and secretion of PGE2. M6PRBP1 also acts positively on HIV-1 and vaccinia virus production.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificates of Analysis (COA)
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Anna V Bulankina et al.
The Journal of cell biology, 185(4), 641-655 (2009-05-20)
TIP47 (tail-interacting protein of 47 kD) was characterized as a cargo selection device for mannose 6-phosphate receptors (MPRs), directing their transport from endosomes to the trans-Golgi network. In contrast, our current analysis shows that cytosolic TIP47 is not recruited to
Jeffrey D Covington et al.
PloS one, 9(3), e91675-e91675 (2014-03-19)
Lipid droplet-associated proteins such as perilipin 3 (PLIN3) and coatomer GTPase proteins (GBF1, ARF1, Sec23a, and ARFRP1) are expressed in skeletal muscle but little is known so far as to their regulation of lipolysis. We aimed here to explore the
Carole Bampi et al.
Virus research, 173(2), 354-363 (2013-01-26)
The cellular tail-interacting 47-kDa protein (TIP47) acts positively on HIV-1 and vaccinia virus production. We show here that TIP47, in contrast, acts as a restriction factor for Sendai virus production. This conclusion is supported by the occurrence of increased or
Fuyuki Nose et al.
PloS one, 8(8), e71542-e71542 (2013-08-13)
Cytosolic lipid droplets (LDs), which are now recognized as multifunctional organelles, accumulate in leukocytes under various inflammatory conditions. However, little is known about the characteristic features of LDs in neutrophils. In this study, we show that perilipin-3 (PLIN3; formerly called
Jeffrey D Covington et al.
European journal of endocrinology, 172(1), 47-58 (2014-10-25)
Polycystic ovary syndrome (PCOS) is associated with reduced adipose tissue lipolysis that can be rescued by aerobic exercise. We aimed to identify differences in the gene expression of perilipins and associated targets in adipose tissue in women with PCOS before
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