GW22011

Anti-GADD45G antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Growth arrest and DNA-damage-inducible protein GADD45 γ
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: chicken
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: rat, human, mouse
• manufacturer/tradename: Genway 15-288-22011
• technique(s): western blot: suitable
• NCBI accession no.: NP_006696.1
• UniProt accession no.: O95257
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... GADD45G(10912)

Description

General description

The gene is mapped to human chromosome 9q22.1-q22.2 and contains a 477-bp open reading frame that encodes a protein of 159 amino acid residues. It is found to be expressed in heart, placenta, liver, skeletal muscle, prostate, testis, and ovary.[1] The active form of GADD45G (growth arrest and DNA-damage-inducible, γ) is a homodimer and its dimerization is essential for apoptosis and growth inhibition.[2]

Immunogen

Immunogen Sequence: GI # 5729836, sequence 1-159

Recombinant growth arrest and DNA-damage-inducible, gamma

Biochem/physiol Actions

GADD45G (growth arrest and DNA-damage-inducible, γ) gene encodes a protein that is expressed in increased levels under stress, growth arrest conditions and treatment with DNA-damaging agents such as UV (ultraviolet) and γ-irradiation. It mediates activation of MTK1/MEKK4 kinase (mitogen-activated protein kinase kinase kinase 4) upon environmental stress, which in turn activates p38 and JNK MAPK (c-Jun N-terminal kinase/ mitogen-activated protein kinase) pathways that regulate cell cycle and apoptosis.[3] The encoded protein functions in DNA repair, negative growth control, genomic stability, cell cycle checkpoints and apoptosis.[2]

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)