GW21475
Anti-PTPRJ (ab1) antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-CD148, Anti-Receptor-type tyrosine-protein phosphatase η
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21475
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PTPRJ(5795)
General description
Protein-tyrosine phosphatase receptor type J (PTPRJ/CD148) is present predominatly in epithelial cells, various tumor cell lines and in lymphocytes. PTPRJ is commonly referred to as CD148 or DEP1.
Immunogen
Immunogen Sequence: GI # 18860900, sequence 206-292
Recombinant protein tyrosine phosphatase, receptor type, J
Biochem/physiol Actions
Protein-tyrosine phosphatase receptor type J (PTPRJ/CD148) is a protein tyrosine phosphatase. It is a negative regulator of T-cell receptor (TCR)-mediated activation of T cells. CD148 affects TCR signaling by interfering with the phosphorylation of phospholipase Cγ1 (PLCγ1) and LAT. CD148 dephosphorylates platelet-derived growth factor β-receptor, resulting in reduction in cell proliferation. CD148 also participates in functioning of cell-cell contacts and adherens junctions. It interacts with p120(ctn), a component of adherens junctions. CD148 associates with receptor tyrosine kinase RET and modulates the tumor phenotype associated with chimeric RET/papillary thyroid carcinoma oncogenes. It dephosphorylates p85 regulatory subunit of phosphoinositide 3-kinase (PI3K) and ERK1/2 (Extracellular signal-regulated kinases). It dephosphorylates and stabilizes epidermal growth factor receptor (EGFR). CD148 negatively regulates Fms-like tyrosine kinase-3 (FLT3) phosphorylation and signaling. It is up-regulated in humans suffering from rheumatoid arthritis and down-regulated in breast tumors.[1] CD148 is a positive regulator of platelet activation and thrombosis.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Richa K Dave et al.
Arthritis research & therapy, 15(5), R108-R108 (2013-09-11)
Monocytic cells play a central role in the aetiology of rheumatoid arthritis, and manipulation of the activation of these cells is an approach currently under investigation to discover new therapies for this and associated diseases. CD148 is a transmembrane tyrosine
Chanel E Smart et al.
PloS one, 7(7), e40742-e40742 (2012-07-21)
The protein tyrosine phosphatase receptor J, PTPRJ, is a tumor suppressor gene that has been implicated in a range of cancers, including breast cancer, yet little is known about its role in normal breast physiology or in mammary gland tumorigenesis.
M A de la Fuente-García et al.
Blood, 91(8), 2800-2809 (1998-05-16)
Evidence is presented showing that a protein tyrosine phosphatase different from CD45 is present on the membrane of human hematopoietic cells. The molecule recognized by the monoclonal antibody 143-41, which has been classified as CD148 in the VI International Workshop
Angela Iervolino et al.
Cancer research, 66(12), 6280-6287 (2006-06-17)
Thyroid cancer is frequently associated with the oncogenic conversion of the RET receptor tyrosine kinase. RET gene rearrangements, which lead to the generation of chimeric RET/papillary thyroid carcinoma (PTC) oncogenes, occur in PTC, whereas RET point mutations occur in familial
Leslie J Holsinger et al.
Oncogene, 21(46), 7067-7076 (2002-10-09)
The receptor-like protein tyrosine phosphatase DEP1, also known as CD148, is expressed predominantly in epithelial cells, in a variety of tumor cell lines, and in lymphocytes. Expression of DEP1 is enhanced at high cell density, and this observation suggests that
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