Immunogen Sequence: GI # 4758760, sequence 259-350
Recombinant adaptor-related protein complex 3, β 2 subunit
Application
Anti-APEB2 antibody produced in chicken is suitable for immunocytochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
AP-3 complex subunit β-2 is a protein encoded by the AP3B2 gene in humans. Adaptor protein 3 (AP-3) is a vesicle-coat protein that forms a heterotetrameric complex and consists of two subunits found in mammalian cells. Ubiquitous AP-3 subunits are expressed in all tissues of the body and neuronal AP-3 subunits may serve neuron-specific functions such as neurotransmitter release. AP-3 seems to localize in the trans-Golgi network and possibly immature secretory vesicles, where it may be involved in the formation of neurosecretory vesicles. It is involved in signal-mediated protein sorting to endosomal-lysosomal organelles and may be dependent on clathrin.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Science (New York, N.Y.), 280(5362), 431-434 (1998-05-09)
A heterotetrameric complex termed AP-3 is involved in signal-mediated protein sorting to endosomal-lysosomal organelles. AP-3 has been proposed to be a component of a nonclathrin coat. In vitro binding assays showed that mammalian AP-3 did associate with clathrin by interaction
Proceedings of the National Academy of Sciences of the United States of America, 103(26), 10035-10040 (2006-06-22)
Adaptor protein 3 (AP-3) is a vesicle-coat protein that forms a heterotetrameric complex. Two types of AP-3 subunits are found in mammalian cells. Ubiquitous AP-3 subunits are expressed in all tissues of the body, including the brain. In addition, there
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
