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GW21361

Sigma-Aldrich

Anti-ITGB7 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Integrin β-7

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About This Item

UNSPSC Code:
12352203

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21361

technique(s)

western blot: suitable

NCBI accession no.

NP_000880.1

UniProt accession no.

P26010

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ITGB7(3695)

Immunogen

Immunogen Sequence: GI # 4504777, sequence 67-136
Recombinant integrin, β 7

Application

Anti-ITGB7 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Integrin β-7 is an integrin protein encoded by the ITGB7 gene in humans. The β7 subunit protein is associated with two integrin α subunits on lymphocytes. One β7 integrin and α4 β7, mediate lymphocyte adhesion to endothelium and to fibronectin. ITGB7 is expressed on naive B cells and memory B cells that traffic to the gastrointestinal tract. The integrins are a large family of heterodimeric cell-surface glycoproteins and play a key role in the adherence of cells to other cells and to extracellular matrix proteins. ITGB7 is also expected to play a role in adhesive interactions of leukocytes. Ligation of β(7) can inhibit the induction of CD38 expression.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
118K1831
029K1728

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M J Guilliano et al.
Journal of immunology (Baltimore, Md. : 1950), 166(4), 2179-2185 (2001-02-13)
Analysis of B cells in the human tonsils identified CD38 expression as a hallmark of germinal center (GC) B cells. However, the signals responsible for the in vivo induction of CD38 have not been determined. The primary site for generation
D J Erle et al.
The Journal of biological chemistry, 266(17), 11009-11016 (1991-06-15)
The integrins are a large family of heterodimeric cell-surface glycoproteins that play key roles in the adherence of cells to other cells and to extracellular matrix proteins. We have previously reported the identification of a novel integrin beta subunit partial
D J Erle et al.
American journal of respiratory cell and molecular biology, 10(3), 237-244 (1994-03-01)
Integrins are heterodimeric cell-surface glycoproteins that mediate cell-cell and cell-matrix adhesion. We previously identified cDNA encoding a novel integrin beta subunit, beta 7, from bronchoalveolar lavage fluid (BALF) leukocytes. The beta 7 subunit protein is now known to associate with

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