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GW21358

Anti-ITGB4 antibody produced in chicken

Name: Anti-ITGB4 antibody produced in chicken
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CD104, Anti-Integrin β-4

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About This Item

MDL number:

MFCD00162574

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21358

technique(s)

western blot: suitable

NCBI accession no.

NP_000204.2

UniProt accession no.

P16144

shipped in

wet ice

Storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ITGB4(3691)

Immunogen

Immunogen Sequence: GI # 21361207, sequence 1441-1520

Recombinant integrin, β 4

Application

Anti-ITGB4 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Integrin, β 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a gene in humans. The downregulation of ITGB4 expression in airway epithelial cells could impair the antigen presentation ability of epithelial cells. It may help in regulating airway inflammation reaction in allergic asthma. ITGB4 expressions are positively correlated in gastric cancer cell lines and tissues and is associated with poor outcomes in gastric cancer patients. It may serve as a therapeutic target in the treatment of gastric cancer. Mutations in ITGB4 cause an autosomal recessive disorder, genodermatosisepidermolysis bullosa with pyloric atresia (EB-PA).

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Metallopanstimulin-1 regulates invasion and migration of gastric cancer cells partially through integrin β4.

Zhong-Yin Yang et al.

Carcinogenesis, 34(12), 2851-2860 (2013-06-28)

MPS-1 (metallopanstimulin-1), also known as ribosomal protein S27, was overexpressed in gastric cancer cells. However, how MPS-1 contributes to gastric carcinogenesis has not been well characterized. Here, we show that high expression of MPS-1 was observed in gastric cancer tissues

Novel ITGB4 mutations in lethal and nonlethal variants of epidermolysis bullosa with pyloric atresia: missense versus nonsense.

L Pulkkinen et al.

American journal of human genetics, 63(5), 1376-1387 (1998-10-30)

Epidermolysis bullosa with pyloric atresia (EB-PA), an autosomal recessive genodermatosis, manifests with neonatal cutaneous blistering associated with congenital pyloric atresia. The disease is frequently lethal, but nonlethal cases have also been reported. Expression of the alpha6 beta4 integrin is altered

Downregulation of integrin β4 decreases the ability of airway epithelial cells to present antigens.

Chi Liu et al.

PloS one, 7(4), e32060-e32060 (2012-05-01)

Airway epithelial cells have been demonstrated to be accessory antigen presentation cells (APC) capable of activating T cells and may play an important role in the development of allergic airway inflammation of asthma. In asthmatic airways, loss of expression of

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