GW21319
Anti-RGS13 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Regulator of G-protein signaling 13
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, mouse, human
manufacturer/tradename
Genway 15-288-21319
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RGS13(6003)
General description
Regulator of G-protein signaling 13 is a protein encoded by the RGS13 gene in humans. It is a member of R4 subfamily of RGS (Regualtors of G Protein Signaling) proteins and is a GTPase-activating protein for Gα(i) and Gα(o). RGS13 helps in suppressing IgE-antigen-induced MC degranulation and anaphylaxis. It is the smallest member of the RGS family and is abundantly found in human tonsil, followed by thymus, lung, lymph node and spleen.
Immunogen
Immunogen Sequence: GI # 4506511, sequence 42-99
Recombinant regulator of G-protein signalling 13
Application
Anti-RGS13 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Regulator of G-protein signaling 13 (RGS13) expression is induced by immune receptor and chemokine receptor stimulation. It may help in regulating Gα(i)-, Gα(q)- and Gα(s)-coupled signaling cascades. RGS13 inhibits the assembly of immune receptor-induced signalosomes in mast cells and its abnormal expression or function may contribute to disorders of amplified mast cell activity (such as idiopathic anaphylaxis). RGS13, along with RGS1, acts together to regulate chemokine receptor signaling in human germinal center B lymphocytes and contribute significantly to the rapid desensitization of the signaling pathway. It restricts certain GPCR-mediated biological responses of human mast cells. RGS13 inhibits cyclic AMP-dependent protein kinase (PKA)-induced gene expression through interactions with the transcription factor cAMP-response element-binding (CREB) protein.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Geetanjali Bansal et al.
Nature immunology, 9(1), 73-80 (2007-11-21)
Mast cells elicit allergic responses through degranulation and release of proinflammatory mediators after antigen crosslinking of the immunoglobulin E receptor FcepsilonRI. Proteins of the 'regulator of G protein signaling' (RGS) family negatively control signaling mediated by G protein-coupled receptors through
Zhihui Xie et al.
Journal of molecular cell biology, 2(6), 357-365 (2010-10-27)
Regulators of G-protein signaling (RGS) proteins are scaffolds that control diverse signaling pathways by modulating signalosome formation and by accelerating the GTPase activity of heterotrimeric G proteins. Although expression of many RGS proteins is relatively low in quiescent cells, transcriptional
Shoko Iwaki et al.
The Journal of biological chemistry, 286(25), 22219-22226 (2011-05-03)
RGS13, a member of the regulator of G protein signaling (RGS) family, inhibits G protein-coupled receptor signaling in B cells and mast cells (MCs) and suppresses IgE-antigen-induced MC degranulation and anaphylaxis. Although RGS13 expression is induced by immune receptor and
Jang-Il Han et al.
Journal of leukocyte biology, 79(6), 1357-1368 (2006-03-28)
Chemokines bind receptors that are members of the G-protein-coupled receptor family. Chemokine receptors transduce intracellular signals by activating heterotrimeric G-proteins. Acting to limit and modulate heterotrimeric G-protein signaling is a family of proteins, termed regulator of G-protein signaling (RGS). Two
Geetanjali Bansal et al.
Journal of immunology (Baltimore, Md. : 1950), 181(11), 7882-7890 (2008-11-20)
IgE-mediated mast cell degranulation and release of vasoactive mediators induced by allergens elicits allergic responses. Although G protein-coupled receptor (GPCR)-induced signals may amplify IgE-dependent degranulation, how GPCR signaling in mast cells is regulated remains incompletely defined. We investigated the role
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