GW21249

Anti-C13orf12 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Chromosome 13 open reading frame 12, Anti-HSPC036 protein
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: chicken
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: mouse, rat, human
• manufacturer/tradename: Genway 15-288-21249
• technique(s): western blot: suitable
• NCBI accession no.: NP_057016.1
• UniProt accession no.: Q9Y244
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... C13orf12(51371)

Description

General description

C13orf12, also called POMP (proteasome maturation protein), is a chaperone protein for proteasome, and has a molecular weight of 16kDa. It is thought to exist as a tetramer with the molecular weight of 64kDa. It is both a cytosolic and a nuclear protein. It has a ubiquitous expression pattern, and the corresponding gene is localized to human chromosome 13q.

Immunogen

Immunogen Sequence: GI # 7705429, sequence 1-141

Recombinant proteasome maturation protein

Application

Anti-C13orf12 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

POMP (proteasome maturation protein), or C13orf12, acts as a chaperone which is essential for the maturation of the 20S proteasome proteolytic core complex. It has an important role in the terminal differentiation of human epidermis. Deletion in this gene is linked with KLICK syndrome, which is a rare autosomal-recessive skin disorder. The deletion results in modified distribution of proteasome in the epidermis, causing altered formation of outer layers of skin.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)