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GW21185

Sigma-Aldrich

Anti-CDKN2A antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

manufacturer/tradename

Genway 15-288-21185

technique(s)

western blot: suitable

NCBI accession no.

NP_000068.1

UniProt accession no.

P42771

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CDKN2A(1029)

Immunogen

Immunogen Sequence: GI # 4502749, sequence 1-51
Recombinant cyclin-dependent kinase inhibitor 2A isoform 1

Application

Anti-CDKN2A antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

p16 (also known as cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor 1) is a tumor suppressor protein encoded by the CDKN2A gene in humans and is mapped on chromosome 9p21. The p16 gene encodes a negative regulator of the cell cycle. It is an important factor in carcinogenesis and its expression is linked to oncogene-induced senescence. p16 upregulation may be associated with the induction of senescence and indicates a senescence barrier while its downregulation is found in malignant progression. Its inhibitor may act as a physiological suppressor of proliferation and cells that are unable to produce the inhibitor may be prone to neoplastic transformation.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
118K1871
039K1924
029K1732

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S Stone et al.
Cancer research, 55(14), 2988-2994 (1995-07-15)
The p16 gene (P16, MTS1, CDKN2) encodes a negative regulator of the cell cycle. Molecular genetic techniques have been used to explore the role of p16 in normal development and cancer. Two transcripts derived from the p16 gene with distinct
T Nobori et al.
Nature, 368(6473), 753-756 (1994-04-21)
Cytogenetic abnormalities of chromosome 9p21 are characteristic of malignant melanomas, gliomas, lung cancers and leukaemias. From a panel of 46 human malignant cell lines, we localized by positional cloning the most frequently deleted region on 9p21. Sequence analysis of the
Lisa M Barnhill et al.
Cancer research, 74(14), 3753-3763 (2014-07-17)
Neuroblastoma is a pediatric cancer with significant genomic and biologic heterogeneity. p16 and ARF, two important tumor-suppressor genes on chromosome 9p21, are inactivated commonly in most cancers, but paradoxically overexpressed in neuroblastoma. Here, we report that exon γ in p16
Thomas Knösel et al.
Journal of clinical pathology, 67(7), 592-598 (2014-04-22)
p16(INK4a) is an important factor in carcinogenesis, and its expression is linked to oncogene-induced senescence. Very recently it was shown that upregulation and downregulation of p16 indicates a senescence barrier in the serrated route of colorectal cancer. However, in soft

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