Immunogen Sequence: GI # 4503603, sequence 255-367
Recombinant estrogen receptor 1
Application
Anti-ESR1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
ERα is encoded by the ESR1 (estrogen receptor 1) gene in humans and is mapped to chmosome 6q25.1. It may play an important role in the development and progression of cerebral infarction. ESR1 genetic polymorphisms may contribute to the development of cerebral infarction. Methylation of ESR1 influences ovarian cancer development and may play a role regarding prognosis of ovarian carcinoma. It may be associated with tumorigenesis of breast cancer.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Journal of cancer research and clinical oncology, 140(10), 1681-1687 (2014-06-09)
Ovarian carcinoma is the third most common gynecological cancer and only short recurrence-free survival and overall survival times are achieved. The role of the estrogen receptor expression is well studied in breast cancer and breast cancer cell lines. Patients with
A number of studies have documented that estrogen receptor α (ESR1) may play an important role in the development and progression of cerebral infarction, but many existing studies have yielded inconclusive results. This meta-analysis was performed to evaluate the relationships
Virchows Archiv : an international journal of pathology, 464(6), 689-699 (2014-04-24)
Immunohistochemical expression of ERα, encoded by the ESR1 (estrogen receptor 1) gene located at 6q25.1, is the most important determinant of responsiveness to endocrine therapy in breast cancer. The prevalence and significance of ESR1 amplification in breast cancer remain controversial.
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