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GW21171

Sigma-Aldrich

Anti-IKBKB antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-IKKB, Anti-IkB kinase β, Anti-Inhibitor of nuclear factor kappa B kinase subunit β

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About This Item

MDL number:
MFCD02263521
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

technique(s)

western blot: suitable

NCBI accession no.

AAC64675.1

UniProt accession no.

O14920

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IKBKB(3551)

Immunogen

Immunogen Sequence: GI # 3213217, sequence 310-376
Recombinant IkB kinase β subunit; IKK β

Application

Anti-IKBKB antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

IKK-β (inhibitor of nuclear factor κ-B kinase subunit β) is a protein encoded by the IKBKB gene in humans. It helps in mediating tumor necrosis-factor α (TNFα) induced invasion of human mesenchymal stem cell (hMSC) to sites of tissue injury. IKK-2 activity suppression leads to reduced expression of proteolytic enzymes and impaired invasive capacity. Its activation is central to NF-κB signaling.[1] IKK-β phosphorylation by IκB kinase (IKK) triggers the degradation of IκB and migration of cytoplasmic κB to the nucleus, where it promotes the transcription of its target genes. It is activated by phosphorylation of its main subunit, IKKβ, at the activation loop sites.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
029K2271
039K2213
039K2068
029K2272

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Shenping Liu et al.
The Journal of biological chemistry, 288(31), 22758-22767 (2013-06-25)
Phosphorylation of inhibitor of nuclear transcription factor κB (IκB) by IκB kinase (IKK) triggers the degradation of IκB and migration of cytoplasmic κB to the nucleus where it promotes the transcription of its target genes. Activation of IKK is achieved
Smarajit Polley et al.
PLoS biology, 11(6), e1001581-e1001581 (2013-06-19)
Activation of the IκB kinase (IKK) is central to NF-κB signaling. However, the precise activation mechanism by which catalytic IKK subunits gain the ability to induce NF-κB transcriptional activity is not well understood. Here we report a 4 Å x-ray
Florian Haasters et al.
Biochemical and biophysical research communications, 436(2), 265-270 (2013-06-08)
IκB kinase 2 (IKK-2) mediates tumor necrosis-factor α (TNFα) induced invasion of human mesenchymal stem cell (hMSC) to sites of tissue injury. Suppressing IKK-2 activity leads to reduced expression of proteolytic enzymes and impaired invasive capacity. In order to further

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