Immunogen Sequence: GI # 10835177, sequence 432-499
Recombinant nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
Application
Anti-NFKB1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Nuclear factor NF-κ-B p105 subunit is a protein encoded by the NFKB1 gene in humans. It is a DNA binding subunit of B-cell protein that interacts with the immunoglobulin κ light-chain gene enhancer. Tumor necrosis factor α (TNF α) helps in activation and induces expression of NFKB1 gene. Oxaliplatin reactivates HIV-1 expression by inducing nuclear factor κ B (NF-κB) nuclear translocation and may be a potential drug candidate for anti-latency therapies.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Proceedings of the National Academy of Sciences of the United States of America, 88(3), 966-970 (1991-02-01)
The DNA binding subunit of nuclear factor kappa B (NF-kappa B), a B-cell protein that interacts with the immunoglobulin kappa light-chain gene enhancer, has been purified from nuclei of human HL-60 cells stimulated with tumor necrosis factor alpha (TNF alpha)
Biochemical and biophysical research communications, 450(1), 202-207 (2014-06-01)
Reactivation of latent HIV-1 is a promising strategy for the clearance of the viral reservoirs. Because of the limitations of current agents, identification of new latency activators is urgently required. Using an established model of HIV-1 latency, we examined the
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