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GW21114

Sigma-Aldrich

Anti-KIT antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-C-Kit, Anti-CD117, Anti-Mast/stem cell growth factor receptor

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21114

technique(s)

western blot: suitable

NCBI accession no.

NP_000213.1

UniProt accession no.

P10721

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KIT(3815)

General description

KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) is a tyrosine kinase receptor, the gene of which is localized to human chromosome 4q12. It is a transmembrane receptor, and is also called CD117. It is expressed by mast cells, hematopoietic progenitor cells, germ cells, melanocytes and interstitial cells of Cajal.

Immunogen

Immunogen Sequence: GI # 4557695, sequence 113-208
Recombinant V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Application

Anti-KIT antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Mutations in receptor tyrosine kinase KIT, plays an important role in the pathogenesis of systemic mastocytosis (SM) and gastrointestinal stromal tumors. KIT tyrosine kinase receptors are implicated in the control of cell growth and differentiation, stem through duplications. KIT and its ligand and the stem cell factor play a key role in normal hematopoiesis.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
049K0556
029K2237

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Alessandra Iurlo et al.
Oncotarget, 5(13), 4665-4670 (2014-07-13)
Activating mutations of KIT receptor tyrosine kinase have been reported in different neoplasms. The M541L KIT substitution (KIT(M541L)) has been described to be associated with pediatric mastocytosis, to enhance growth rate of the affected cells and to confer higher sensitivity
Abbas Ahmadi et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(7), 6763-6768 (2014-04-12)
C-kit receptor (CD117) and its ligand, stem cell factor, play a key role in normal hematopoiesis. It has been demonstrated that its expression extremely increases in leukemias with myeloid commitment. We analyzed findings on CD117 expression together with other myeloid
C Andre et al.
Genomics, 39(2), 216-226 (1997-01-15)
The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor. We have conducted a detailed structural analysis of the two loci containing the KIT and
Yanli Jin et al.
Cancer letters, 353(1), 115-123 (2014-08-05)
Gain-of-function mutations of receptor tyrosine kinase KIT play a critical role in the pathogenesis of systemic mastocytosis (SM) and gastrointestinal stromal tumors. D816V KIT mutation, found in ∼80% of SM, is resistant to the currently available tyrosine kinase inhibitors (TKIs)

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