GW21102
Anti-CXCL13 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-SCYB13, Anti-Small inducible cytokine B13
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21102
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CXCL13(10563)
Immunogen
Immunogen Sequence: GI # 5453577, sequence 65-94
Recombinant chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
Application
Anti-CXCL13 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
C-X-C motif chemokine 13 (CXCL13) is a protein (B-cell chemokine) encoded by the CXCL13 gene in humans. It functions as a ligand and may guide B lymphocytes to follicles in secondary lymphoid organs. CXCL13 mediates B-cell trafficking and get increased proportionately to disease activity, in many antibody-mediated syndromes. Its level is increased and is a prognostic biomarker in patients with idiopathic pulmonary fibrosis (IPF) and COPD. CXCL13 concentration is found to be significantly elevated in the cerebrospinal fluid (CSF) of the group with aseptic meningoencephalitis compared with the group with aseptic meningitis. It may act as a useful marker for predicting the prognosis of aseptic meningitis. CXCL13 may also act as an a biomarker in multiple sclerosis.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Enrique Alvarez et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 19(9), 1204-1208 (2013-01-17)
CXCL13, a B-cell chemokine, has been proposed as a biomarker in a variety of conditions, some of which can mimic multiple sclerosis and can have very high levels. In this case-control study, cerebrospinal fluid (CSF) CXCL13 was elevated in multiple
Juichi Fujimori et al.
Journal of neuroimmunology, 273(1-2), 77-84 (2014-06-09)
In exceptional cases, patients with aseptic meningitis eventually develop aseptic meningoencephalitis. To find a candidate marker for the development of aseptic meningoencephalitis in adult patients diagnosed with aseptic meningitis, we compared 12 different cytokines/chemokines in cerebrospinal fluid (CSF) from 5
Louis J Vuga et al.
American journal of respiratory and critical care medicine, 189(8), 966-974 (2014-03-19)
C-X-C motif chemokine 13 (CXCL13) mediates B-cell trafficking and is increased, proportionately to disease activity, in many antibody-mediated syndromes. Dysregulated B cells have recently been implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis. To determine if CXCL13 is associated with IPF
M D Gunn et al.
Nature, 391(6669), 799-803 (1998-03-05)
Secondary lymphoid organs (spleen, lymph nodes and Peyer's patches) are divided into compartments, such as B-cell zones (follicles) and T-cell zones, which provide specialized environments for specific steps of the immune response. Migration of lymphocyte subsets into these compartments is
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