PPBP (pro-platelet basic protein), also called CXCL7 (chemokine (C-X-C motif) ligand 7), is synthesized as a pro-peptide, which has a molecular weight of 14kDa. It undergoes proteolytic cleavage to produce multiple forms with different biological activities. The longest form produced post cleavage is called PPBP or LDGF (leukocyte-derived growth factor), and is a mitogen for fibroblast cells.
Anti-Platelet Basic Protein antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
PPBP (pro-platelet basic protein), also called chemokine (C-X-C motif) ligand 7 (CXCL7), plays a role in immune response of human phagocytes against the intracellular bacteria. It is found at a significantly higher level in patients with rheumatoid arthritis, which is a chronic inflammatory disease. CXCL7 may act as a helper marker in the follow-up and treatment of developing cardiovascular risk.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
The activation of the platelets plays a key role in the formation of thrombosis. The variables such as mean platelet volume, platelet factor 4 and β-thromboglobulin have been used in the demonstration of the platelet activation. However, when the literature
We have investigated the role of CXCL7 in the immune response of human phagocytes against the intracellular bacteria Mycobacterium tuberculosis and Legionella pneumophila. We have observed that polymorphonuclear neutrophil (PMN) chemotaxis induced by the supernatants of infected monocyte derived macrophages
The marrow microenvironment consists of several different interacting cell types, including hematopoietic-derived monocyte/macrophages and nonhematopoietic-derived stromal cells. Gene-expression profiles of stromal cells and monocytes cultured together differ from those of each population alone. Here, we report that CXCL7 gene expression
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