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GW21071

Anti-PI3K antibody produced in chicken

Name: Anti-PI3K antibody produced in chicken
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit β isoform

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

technique(s)

western blot: suitable

NCBI accession no.

NP_006210.1

UniProt accession no.

P42338

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PIK3CB(5291)

Immunogen

Immunogen Sequence: GI # 5453894, sequence 58-134

Recombinant phosphoinositide-3-kinase, catalytic, β polypeptide

Application

Anti-PI3K antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit β isoform is an enzyme encoded by the PIK3CB gene in humans. It has been implicated as a participant in signaling pathways regulating cell growth by virtue of its activation in response to various mitogenic stimuli. PI 3-kinase exhibits different isoforms and has a define family of genes encoding distinct PI 3-kinase catalytic subunits that can associate with p85. It is commonly activated in tumors. PI3K pathway is activated in tumors and most commonly through p110α mutation or PTEN deletion.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lan Liu et al.

Oncology letters, 14(3), 3741-3747 (2017-09-21)

Catalpol is an effective active ingredient that functions as a diuretic and laxative, and exhibits blood sugar-lowering, liver protective, anti-aging and anticancer effects. In traditional Chinese medicine, catalpol is believed to be Yin nourishing. The anticancer effect of catalpol on

Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase.

Hashem A Dbouk et al.

PloS one, 8(5), e63833-e63833 (2013-06-05)

The PI3-kinase pathway is commonly activated in tumors, most often by loss of PTEN lipid phosphatase activity or the amplification or mutation of p110α. Oncogenic mutants have commonly been found in p110α, but rarely in any of the other catalytic

Long non‑coding RNA MEG3 inhibits cell migration and invasion of non‑small cell lung cancer cells by regulating the miR‑21‑5p/PTEN axis.

Dongjin Lv et al.

Molecular medicine reports, 23(3) (2021-01-27)

Long non‑coding RNAs (lncRNAs) are involved in the occurrence and progression of numerous types of cancer. The aim of the present study was to evaluate the effect of the lncRNA maternally expressed gene 3 (MEG3) on the migration and invasion of

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.

P Hu et al.

Molecular and cellular biology, 13(12), 7677-7688 (1993-12-01)

Phosphatidylinositol 3-kinase (PI 3-kinase) has been implicated as a participant in signaling pathways regulating cell growth by virtue of its activation in response to various mitogenic stimuli. Here we describe the cloning of a novel and ubiquitously expressed human PI

A beta version of life: p110β takes center stage.